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Extrinsic and Intrinsic Regulation of DOR/TRP53INP2 Expression in Mice

ABSTRACT: The objective is to relate changes in expression of DOR/TRP53INP2, a factor involved in thyroid hormone action and autophagy, to body composition in mice fed a fat (FD) or high fat diet (HFD) for 8 days and in a genetically obese mouse model. We conclude that DOR expression depends on sex, fat content of diet, age, tissue type and tissue weight.

ORGANISM(S): Mus musculus

PROVIDER: GSE32872 | GEO | 2014/09/30

SECONDARY ACCESSION(S): PRJNA146597

REPOSITORIES: GEO

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Extrinsic and Intrinsic Regulation of DOR/TRP53INP2 Expression in Mice

Project description:The objective is to relate changes in expression of DOR/TRP53INP2, a factor involved in thyroid hormone action and autophagy, to body composition in mice fed a fat (FD) or high fat diet (HFD) for 8 days and in a genetically obese mouse model. We conclude that DOR expression depends on sex, fat content of diet, age, tissue type and tissue weight. 4 samples: 2 (normal diet control, fat diet) x2 replicates

2014-09-30 | E-GEOD-32872 | biostudies-arrayexpress

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2022-01-26 | PXD021046 | Pride

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2019-04-09 | E-MTAB-7755 | biostudies-arrayexpress

Gene expression profiling of adipocyte and stromal vascular cells from adipose tissue in lean, obese and formerly obese mice

Project description:To investigate the transcriptional profiles of adipocytes and stromal vascular cells from mouse visceral adipose tissue(vWAT) in lean (Low fat diet, LFD fed), obese (high fat diet, HFD fed) and formerly obese (diet switch (SW) from 9 weeks HFD, to 3 weeks LFD) to induce weight loss.

2022-08-04 | GSE210014 | GEO

High-fat diet decreases expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in adipose tissue, along with increased expression of extracellular matrix remodeling- and inflammation-related genes

Project description:We identified differentially expressed genes in epididymal white adipose tissue of high fat diet(HFD)-fed mice compared to low fat diet-fed mice using microarray analysis. Microarray analysis revealed that genes related to lipolysis, fatty acid metabolism, mitochondrial energy transduction, oxidation-reduction, insulin sensitivity, and skeletal system development were downregulated in HFD-fed mice, and genes associated with extracellular matrix (ECM) components, ECM remodeling, and inflammation were upregulated. The top 10 up- or downregulated genes include Acsm3, mt-Nd6, Fam13a, Cyp2e1, Rgs1, and Gpnmb, whose roles in obesity-associated adipose tissue deterioration are poorly understood. Total RNA of epididymal white adipose tissue was obtained from low fat diet (10 kcal% fat)- and high fat diet(45 kcal% fat)-fed mice and mRNA expression was measured using microarray analysis.

2015-07-01 | E-GEOD-63198 | biostudies-arrayexpress

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2018-04-12 | MSV000082272 | MassIVE

Proteomics of liver from mice fed high fat diet (HFD) or regular chow diet

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Molecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 1)

Project description:In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabetic on normal diet). In this model one can search for parameters that distinguish females fed normal diet compared to high fat diet (i.e. components that vary with the development of diabetes) and evaluate if such changes can be related to components that characterize male diabetic animals.. Biological replicates: 4 ZDF female rat livers from rats on a standard diet (SD) and 4 ZDF female rat livers from rats on high-fat diet (HFD) (6 weeks). One replicate per array. Hepatic gene expression, hepatic metabolites, sex-differences

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Transcription profiling of Arabidopsis dor mutant and wild type plants in response to drought stress.

Project description:ATH1 GeneChip was used for gene expression analysis of wild-type plants and dor mutant under drought treatment (both the wild-type and dor plants were grown under normal watering conditions for 24 days and then stressed by completely depriving of irrigation for 10 days). Two biological repeat experiments were conducted and the raw data was analyzed applying Affymetrix GCOS software. Experiment Overall Design: ATH1 GeneChip was used for gene expression analysis of wild-type plants and dor mutant under drought treatment (both the wild-type and dor plants were grown under normal watering conditions for 24 days and then stressed by completely depriving of irrigation for 10 days).

2008-10-26 | E-GEOD-10643 | biostudies-arrayexpress

Transcription profiling of Arabidopsis dor mutant and wild-type plants in response to drought stress.

Project description:ATH1 GeneChip was used for gene expression analysis of wild-type plants and dor mutant under drought treatment (both the wild-type and dor plants were grown under normal watering conditions for 24 days and then stressed by completely depriving of irrigation for 10 days). Two biological repeat experiments were conducted and the raw data was analyzed applying Affymetrix GCOS software. Keywords: both the wild-type and dor plants were grown under normal watering conditions for 24 days and then stressed for 10 days

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