Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular profiling and gene expression analysis in cutaneous sarcoidosis (CS)

ABSTRACT: Cutaneous sarcoidosis skin provides relatively non invasive access to granulomatous sarcoidosis tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE32887 | GEO | 2011/10/13

SECONDARY ACCESSION(S): PRJNA146621

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Molecular profiling and gene expression analysis in cutaneous sarcoidosis (CS)

Project description:Cutaneous sarcoidosis skin provides relatively non invasive access to granulomatous sarcoidosis tissue. Twenty participants were enrolled: 15 with active CS and 5 healthy volunteers. Microarray analyses comparing non-LS and healthy volunteer skin with LS showed several thousand genes differentially expressed

2011-10-12 | E-GEOD-32887 | biostudies-arrayexpress

Evaluation of tofacitinib in cutaneous sarcoidosis

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis

| PRJNA715446 | ENA

Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis

Project description:Sarcoidosis is a granulomatous disease of unknown cause. We performed single-cell RNA sequencing to identify the macrophages that comprise sarcoidosis granulomas.

2023-09-25 | GSE234901 | GEO

Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis

2012-07-01 | GSE37912 | GEO

Evaluation of tofacitinib in cutaneous sarcoidosis [scRNA-seq]

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis [scRNA-seq]

| PRJNA715583 | ENA

Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis

Project description:Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ~20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated sarcoidosis). Unfortunately, current biomarkers fail to distinguish patients with remitting (uncomplicated) sarcoidosis from other fibrotic lung disorders, and fail to identify individuals at risk for complicated sarcoidosis. We utilized genome-wide peripheral blood gene expression analysis to identify a gene signature distinguishing sarcoidosis from healthy controls, which also served as a molecular signature for complicated sarcoidosis. Total RNA was isolated from PBMCs using standard molecular biology protocols without DNA contamination or RNA degradation. Sample processing (e.g., cDNA generation, fragmentation, end labeling, hybridization to Affymetrix GeneChip Human Exon 1.0 ST arrays) was performed per manufacturer’s instructions. A total of 29 African descent American (AA) and 10 European descent American (EA) patients with sarcoidosis were included in the overall sarcoidosis cohort with 18 AA and 4 EA patients diagnosed with complicated sarcoidosis.

2012-06-30 | E-GEOD-37912 | biostudies-arrayexpress

Evaluation of tofacitinib in cutaneous sarcoidosis [bulk RNA-seq]

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis [bulk RNA-seq]

| PRJNA715582 | ENA

Evaluation of tofacitinib in cutaneous sarcoidosis [Olink Explore 1536]

Project description:Evaluation of tofacitinib in cutaneous sarcoidosis [Olink Explore 1536]

| PRJNA715584 | ENA

Evaluation of tofacitinib in cutaneous sarcoidosis [scRNA-seq]

Project description:Sarcoidosis is a multisystem inflammatory disease and no molecularly targeted therapies exist. Here we evaluate the efficacy of tofacitinib (a JAK1/3 inhibitor) in an open-label trial of 10 patients with sarcoidosis and correlate clinical improvement with molecular parameters in blood and skin.

2022-03-30 | GSE169147 | GEO

Gene expression data in CD4+ and CD8+ cells in sarcoidosis patients following antimycobacterial therapy

Project description:Many chronic cutaneous diseases associated with microbial antigens demonstrate clinical progression due to T cell hyporesponsiveness. Appropriate antimicrobial therapy restores T cell function, leading to clinical resolution. Due to the association of sarcoidosis with mycobacterial antigens, we compared the efficacy of antimycobacterial therapy with placebo in chronic cutaneous sarcoidosis.

2013-07-23 | GSE39606 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data