Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.

ABSTRACT: Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. We found that compound C (also known as dorsomorphin) prevented the UPR and exerted enhanced cytotoxicity during glucose deprivation. The UPR-inhibiting activity of compound C was not associated with either AMPK or BMP signaling inhibition.

ORGANISM(S): Homo sapiens

PROVIDER: GSE32911 | GEO | 2012/10/11

SECONDARY ACCESSION(S): PRJNA146537

REPOSITORIES: GEO