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IL-2/CD25 Fusion Protein Enhances Expansion of Antigen-Specific CD8⁺ T Cells to Suppress Hepatocellular Carcinoma

ABSTRACT: To investigated how IL-2/CD25 change the Immune microenvironment of hepatocelluar carcinoma

ORGANISM(S): Mus musculus

PROVIDER: GSE329148 | GEO | 2026/07/02

REPOSITORIES: GEO

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IL-2/CD25 Fusion Protein Enhances Expansion of Antigen-Specific CD8⁺ T Cells to Suppress Hepatocellular Carcinoma

Project description:IL-2/CD25 Fusion Protein Enhances Expansion of Antigen-Specific CD8⁺ T Cells to Suppress Hepatocellular Carcinoma

| PRJNA1458053 | ENA

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells

Project description:Low-dose IL-2 represents an immunotherapy to selectively expand regulatory T cells (Tregs) to promote tolerance in patients with autoimmunity. In this article, we show that a fusion protein (FP) of mouse IL-2 and mouse IL-2Rα (CD25), joined by a noncleavable linker, has greater in vivo efficacy than rIL-2 at Treg expansion and control of autoimmunity. Biochemical and functional studies support a model in which IL-2 interacts with CD25 in the context of this FP in trans to form inactive head-to-tail dimers that slowly dissociate into an active monomer. In vitro, IL-2/CD25 has low sp. act. However, in vivo IL-2/CD25 is long lived to persistently and selectively stimulate Tregs. In female NOD mice, IL-2/CD25 administration increased Tregs within the pancreas and reduced the instance of spontaneous diabetes. Thus, IL-2/CD25 represents a distinct class of IL-2 FPs with the potential for clinical development for use in autoimmunity or other disorders of an overactive immune response.

2018-08-27 | GSE113951 | GEO

BioID of CD25 mutants in B-cell malignancies

Project description:CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing construct was used as negative control.

2026-02-23 | PXD035989 | Pride

Naive CD4+ T cell expansion defined by CD25 and CD31 expression

Project description:Naive CD4 T cells defined as (TCRab+ CD4+ CD45RA+ CD62L+ CD127+) were further divided by CD25 and CD31 expression with FACS-based flow sorting. Subsequently, gene expression levels of each subset were assessed by using transcription arrays.

2017-08-15 | E-MTAB-4853 | biostudies-arrayexpress

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.

Project description: Not available

| S-EPMC1550279 | biostudies-literature

Two functionally distinct subsets of mast cells generated through IL-2 independent CD25 activities

Project description:CD25 (IL-2R) can be expressed on the surface of immune cells in the absence of other chains of the interleukin-2 receptor (IL-2R), which are indispensable for IL-2 signaling. We identified two novel mast cell subsets, characterized by the differential expression of surface CD25, and by the ability to produce different cytokines and to proliferate, both in vitro and in vivo. We provide evidence that functional differences between the two mast cell populations were dependent on CD25 itself, which directly modulated mast cell proliferation and responses in vivo. These effects were completely independent from IL-2 or the expression of the other chains of the high-affinity IL-2R, indicating an autonomous and previously unappreciated role for CD25 in regulating cell functions. Similar results were also obtained in dendritic cells, which are known to express CD25 but to be unresponsive to IL-2. Our findings indicate a general role for CD25 in contexts where IL-2 signaling is not involved, and may have important implications for all mast cell-related diseases, including mastocytosis, where CD25 is aberrantly expressed on pathogenic mast cells.

2014-08-03 | GSE52502 | GEO

Two functionally distinct subsets of mast cells generated through IL-2 independent CD25 activities

2014-08-03 | E-GEOD-52502 | biostudies-arrayexpress

Transcription profiling of mouse CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells

Project description:Comparison of gene expression profile of CD4+ CD25+, CD4+ CD25- CD45RBlow LAG3+ and CD4+ CD25- CD45RBlow LAG3- T cells. Naive CD4+CD25-CD45RBhigh T cells were used as a reference for pair comparison with values from the three other subsets.

2009-08-19 | E-MEXP-1343 | biostudies-arrayexpress

Phospho-Tyrosine analysis of the effect of CD25 KO in pre-B-ALL cells

Project description:To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before tratment with 4-OHT to induce CD25 KO. Phospho-Tyrosine proteomics was performed and differential phosphosites analysed in Cre-ERT2 vs ERT2 samples.

2026-02-23 | PXD036128 | Pride

Expression of CD25 in human lung mast cells and its regulation by IL-33

Project description:Expression of CD25 in human mast cells is primarily associated with aberrant mast cell in clonal mast cell disorders. The regulation of its expression remains undefined. We investigate the role of IL-33 in regulating CD25 in primary human lung mast cells (HLMCs) and the functional consequence of this regulation.

2026-03-19 | GSE314641 | GEO

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