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Transcriptomic profiling of Visceral Adipose Tissue (VAT) in a neonatal STZ-induced diabetes model: modulatory effects of Curcumin. [RNA-Seq]

ABSTRACT: Visceral Adipose Tissue (VAT) plays a pivotal role in the systemic metabolic complications of Type 2 Diabetes, acting as a primary site for pro-inflammatory cytokine secretion and lipid storage failure. In this study, we utilized a combined neonatal Streptozotocin (nSTZ) and High-Fat Diet (HFD) model to simulate the progression of diabetic adipopathy in C57BL/6 mice. The objective was to characterize the transcriptomic response of VAT to chronic hyperglycemia and lipid overload, and to evaluate the potential of Curcumin (50 mg/kg) as a metabolic and inflammatory modulator. Following 28 days of daily treatment via oral gavage, VAT samples were collected for total RNA sequencing. These data contribute to the understanding of the molecular mechanisms underlying adipose tissue dysfunction in diabetes and highlight the role of Curcumin in modulating the transcriptomic profile landscape to improve metabolic health.

ORGANISM(S): Mus musculus

PROVIDER: GSE329567 | GEO | 2026/05/04

REPOSITORIES: GEO

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