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A Conserved Natural Killer Cell Transcriptional Fingerprint in Rhesus Macaque Models of Acute Viral Infections [RNA-seq_SIVmac251]

ABSTRACT: In this study, we utilize a rhesus macaque (RM) model to define the transcriptomic profile of NK cells during acute lentiviral infection and to map the changes in this profile as infection progresses to the early chronic phase. Using a novel summary gene set for NK cell cytokine stimulation, we report synchronous metabolic and signaling transcriptional patterns that underlie established features of NK cell dysfunction. We further identify a set of core conserved gene pathways central to RM NK cell activation across diverse acute viral contexts.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE329639 | GEO | 2026/06/03

REPOSITORIES: GEO

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A Conserved Natural Killer Cell Transcriptional Fingerprint in Rhesus Macaque Models of Acute Viral Infections [RNA-seq_SIVmac239]

Project description:In this study, we utilize a rhesus macaque (RM) model to define the transcriptomic profile of NK cells during acute lentiviral infection and to map the changes in this profile as infection progresses to the early chronic phase. Using a novel summary gene set for NK cell cytokine stimulation, we report synchronous metabolic and signaling transcriptional patterns that underlie established features of NK cell dysfunction. We further identify a set of core conserved gene pathways central to RM NK cell activation across diverse acute viral contexts.

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A Conserved Natural Killer Cell Transcriptional Fingerprint in Rhesus Macaque Models of Acute Viral Infections [RNA-seq_SIVmac239]

Project description:A Conserved Natural Killer Cell Transcriptional Fingerprint in Rhesus Macaque Models of Acute Viral Infections [RNA-seq_SIVmac239]

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2025-12-09 | GSE286121 | GEO

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