Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bulk RNA-sequencing analyses of multi-stroma flow-sorted from cocultures with murine pancreatitis (P)-derived organoids, PDAC organoids, or PDAC organoids following initial coculture with P organoids (ie P-to-PDAC or sequential).

ABSTRACT: We investigated the transcriptomic differences of multi-stroma flow-sorted from cocultures with murine pancreatitis (P)-derived organoids, PDAC organoids, or PDAC organoids following initial coculture with P organoids (ie P-to-PDAC or sequential).

ORGANISM(S): Mus musculus

PROVIDER: GSE329640 | GEO | 2026/07/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Analysis of pancreatitis-derived organoids and PDAC organoids cocultured with multi-stroma

Project description:We investigated the crosstalk between cocultures of pancreatitis (P)-derived organoids (P1 or P5) or PDAC organoids (T6-LOH or T13-LOH) and multi-stroma (pancreatic stellate cells PSC5, pancreatic fibroblasts FIBRO27 and mesothelial cells M-G1).

2026-07-02 | GSE311279 | GEO

Bulk RNA-sequencing analyses of multi-stroma flow-sorted from cocultures with murine pancreatitis (P)-derived organoids, PDAC organoids, or PDAC organoids following initial coculture with P organoids (ie P-to-PDAC or sequential).

Project description:Bulk RNA-sequencing analyses of multi-stroma flow-sorted from cocultures with murine pancreatitis (P)-derived organoids, PDAC organoids, or PDAC organoids following initial coculture with P organoids (ie P-to-PDAC or sequential).

| PRJNA1460364 | ENA

Analysis of murine normal pancreatic organoids, pancreatitis-derived organoids, and PDAC organoids in complete media and of pancreatitis-derived organoids, and PDAC organoids cultured alone or cocultured with pancreatic stellate cells in reduced media

Project description:We investigated the differences between murine normal pancreatic organoids (N), pancreatitis-derived organoids (P), and PDAC organoids cultured in completed media (i.e., mCPLT). We also studied the crosstalks between P and PDAC organoids and PSCs when they are cocultured together (i.e., cocx) or in monoculture (i.e., monocx) in reduced media.

2026-07-02 | GSE311286 | GEO

Analysis of pancreatitis-derived organoids and PDAC organoids cocultured with multi-stroma

Project description:Analysis of pancreatitis-derived organoids and PDAC organoids cocultured with multi-stroma

| PRJNA1368868 | ENA

Analysis of murine pancreatitis tissues and KPC PDAC tumours

Project description:We investigate the pancreatitis tissues from carulein-induced mice and PDAC tumours from KPC genetically engineered mice.

2026-07-02 | GSE311531 | GEO

Microarray gene-expression data to validate a 17-gene biomarker obtained from excessive meta-analysis to test its PDAC specificity in the presence of pancreatitis tissues.

Project description:Clinical signs and radiographic findings of PDAC and pancreatitis are often indistinguishable, highlighting the need of a PDAC biomarker to be insensitive to pancreatitis. Therefore we validated a biomarker signature of 17-genes in this gene expression data containing PDAC, non-tumor pancreatic and pancreatitis of fresh-frozen and formalin-fixed paraffin-embedded tissues.

2018-05-11 | GSE101462 | GEO

Analysis of murine pancreatitis tissues and KPC PDAC tumours

Project description:Analysis of murine pancreatitis tissues and KPC PDAC tumours

| PRJNA1369607 | ENA

Single-cell spatial transcriptomics analysis of murine normal pancreas (N), pancreatitis (P), and PDAC formalin-fixed paraffin-embedded (FFPE) samples using Visium HD.

Project description:We investigated the single-cell spatial transcriptomics of murine normal pancreas (N), pancreatitis (P) and PDAC formalin-fixed paraffin-embedded (FFPE) samples using Visium HD.

2026-07-02 | GSE329811 | GEO

Profiling of Kallikrein Proteases and Global Proteome Biology of PDAC, Chronic Pancreatitis and Normal Pancreas

Project description:Cell conditioned medium from human pancreatic cancer cell lines MiaPaCa-2, AsPC-1, primary pancreatic cell lines as well as human FFPE tissue samples from pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), ampullary cancer, non-malignant adjacent pancreas and normal pancreas were analyzed via targeted (SRM, PRM) and/or explorative (DIA) mass spectrometry.

| MSV000090255 | MassIVE

Gene expression of matched treatment-naive versus FOLFIRINOX-treated PDAC patient-derived organoids

Project description:In our study, we aimed to investigate adaptive processes of tumors under treatment and therefore, generated PDAC patient-derived organoids (PDOs) and 2D cell lines before and after chemotherapy. We enrolled a patient with borderline resectable PDAC who received neoadjuvant FOLFIRINOX. Endoscopic fine needle (pre-FFX) and surgical biopsies (post-FFX) were used to generate PDOs and 2D cells. Whole exome sequencing (WES) and RNA sequencing data of the pre-FFX and post-FFX organoids were compared in order to evaluate the genetic landscape and PDAC subtypes. Although transcriptional subtyping classified both PDOs as classical PDAC, gene set enrichment analysis (GSEA) revealed a reduced pathway activation linked to the basal-like phenotype such as KRAS signaling in the post-FFX organoids. WES did not show major differences in the genetic landscape of the tumor pre- and post-FFX induction suggesting a plasticity process rather than a clonal selection during chemotherapy. 2D cells were subjected to an unbiased automated drug screening of 415 compounds to investigate FFX-induced vulnerabilities. Top targets such as MEK inhibitors were validated manually in the 2D cells and organoids and an increased sensitivity was observed in the post-FFX cells. Thus, integrating functional layers into personalized medicine allows to identify chemotherapy-induced vulnerabilities as potent targeted therapy options in PDAC.

2022-03-09 | GSE193389 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data