Other

Dataset Information

0

Induced transcription in a gene desert region advanced replication timing


ABSTRACT: This study investigates whether transcription can directly reorganize DNA replication timing. To isolate the effect of transcription from native chromatin context, we established an inducible transcription system within a large late-replicating gene desert on mouse chromosome 2. Using Repli-seq, we found that induced transcription is sufficient to advance replication timing across an approximately 800-kb genomic domain. The induced early-replicating domain displayed an asymmetric replication timing profile relative to the knock-in site, and this asymmetry was independent of transcriptional direction. Genome-wide analysis further showed that pronounced asymmetry is uncommon among native early-replicating domains. These data provide direct evidence that transcription can reshape large-scale replication timing.

ORGANISM(S): Mus musculus

PROVIDER: GSE329934 | GEO | 2026/07/25

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-09-30 | GSE167045 | GEO
2019-01-23 | GSE98730 | GEO
2019-01-23 | GSE98714 | GEO
2019-01-23 | GSE124274 | GEO
2021-09-21 | GSE159664 | GEO
2021-09-21 | GSE158009 | GEO
2021-09-21 | GSE158008 | GEO
2021-09-21 | GSE158007 | GEO
2021-09-21 | GSE158010 | GEO
2021-09-21 | GSE159663 | GEO