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Genome-wide DNA methylation profiling of CpG islands in breast cancer

ABSTRACT: Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve prognosis and treatment of advanced cancer patients. In this study, we performed a genome-wide profile of DNA methylation patterns in sporadic breast tumors by using the HumanMethylation27 BeadChips to assess relationships between DNA methylation changes and patient tumor characteristics. The arrays identified 264 hypermethylated loci/genes present in breast cancer genomes

ORGANISM(S): Homo sapiens

PROVIDER: GSE33065 | GEO | 2012/04/30

SECONDARY ACCESSION(S): PRJNA149485

REPOSITORIES: GEO

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Genome-wide DNA methylation profiling of CpG islands in breast cancer

Project description:Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve prognosis and treatment of advanced cancer patients. In this study, we performed a genome-wide profile of DNA methylation patterns in sporadic breast tumors by using the HumanMethylation27 BeadChips to assess relationships between DNA methylation changes and patient tumor characteristics. The arrays identified 264 hypermethylated loci/genes present in breast cancer genomes This study has used the Illumina HumanMethylation27 BeadChip to assess methylation levels of 39 sporadic ductal carcinomas and 4 additional sporadic ductal carcinoma samples. Four normal breast tissue DNA samples were used as controls that were sourced from the same patient as the 4 additional tumour samples.

2012-04-29 | E-GEOD-33065 | biostudies-arrayexpress

A genome-wide methylation study on essential hypertension in young African American Males

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Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape [blood]

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Project description:We performed a genome wide methylation scan using the Illumina HumanMethylation27 BeadChip on DNAs extracted from the leukocytes of 7 obese (BMI?99th percentile for age and sex) and 7 lean (BMI?10th percentile for age and sex) African American males aged 14-18 years. Bisulphite converted DNA from the 14 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

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Polycomb-like proteins link the PRC2 complex to CpG islands

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