Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GALNT3-deletion suppresses inflammation-associated fibrosis to ameliorates chronic kidney disease via inactivating the TNF-α/NF-kB/MAPK signaling pathway

ABSTRACT: Chronic kidney disease (CKD) seriously degrades the life quality of human beings, but the molecular mechanisms that drive CKD pathogenesis have not been fully delineated.

ORGANISM(S): Mus musculus

PROVIDER: GSE330842 | GEO | 2026/05/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GALNT3-deletion suppresses inflammation-associated fibrosis to ameliorates chronic kidney disease via inactivating the TNF-α/NF-kB/MAPK signaling pathway

Project description:GALNT3-deletion suppresses inflammation-associated fibrosis to ameliorates chronic kidney disease via inactivating the TNF-α/NF-kB/MAPK signaling pathway

| PRJNA1465776 | ENA

Levo-tetrahydropalmatine Ameliorates Neuropathic Pain via Suppressing the Activation of the Clec7a-MAPK/NF-κB-NLRP3 Inflammasome Axis

Project description:Due to the complex pathogenesis of neuropathic pain (NP), the therapeutic effect of existing drugs on NP is not satisfactory, which seriously affects the life quality of patients. Accumulating studies have indicated that neuroinflammation in the spinal cord may play a vital role in NP development and progression. Levo-tetrahydropalmatine (l-THP) has been extensively used for the treatment of a variety of chronic pain for decades. However, the analgesic effects and the underlying mechanisms of I-THP against NP have not been fully elucidated. To address this problem, we herein carried out RNA-seq and bioinformatics analyses to identify the effective target profiling of I-THP including 1113 upregulated and 132 downregulated genes in spinal cord obtained from Chronic constrictive injury (CCI) rats with or without I-THP administration.

2023-05-05 | GSE217932 | GEO