TGFβ-Dependent Epithelial–Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study

ABSTRACT: The adult mammalian heart exhibits limited regenerative capacity, and a stable adult human in vitro model for investigating epicardial activation remain limited. Here, we isolated human epicardium-derived cells from the adult heart auricle. Successful immortalization led to the generation of a stable immortalized epicardium-derived cell (iEPDC) population, allowing the investigation of intercellular dynamics upon EMT activation. TGFβ signalling was modulated using SB431542 or TGFβ3.

ORGANISM(S): Homo sapiens

PROVIDER: GSE330909 | GEO | 2026/07/23

REPOSITORIES: GEO