Epicardial fat drives macrophage response in atrial cardiomyopathy [scRNA-Seq]

ABSTRACT: Single-cell RNA sequencing was performed on atrial cells isolated from mice fed either normal diet (ND) or high-fat diet (HFD) for 2 or 4 months to investigate immune and stromal remodeling during obesity-associated atrial cardiomyopathy. Distinct Lyve1+ resident and CCR2+ monocyte-derived macrophage populations were identified in obese mouse atria and were associated with atrial adiposity, fibro-fatty remodeling, and atrial fibrillation progression.

ORGANISM(S): Mus musculus

PROVIDER: GSE331465 | GEO | 2026/05/20

REPOSITORIES: GEO