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Bulk RNA-seq analysis of wild-type and LRRC8A knockout primary mouse aortic vascular smooth muscle cells

ABSTRACT: LRRC8A-containing volume-regulated anion channels regulate redox signaling, inflammatory transcriptional activity, metabolism, and senescence in vascular smooth muscle cells. To define transcriptional changes caused by LRRC8A deletion, bulk RNA sequencing was performed on primary cultured mouse aortic vascular smooth muscle cells isolated from wild-type and smooth muscle-specific LRRC8A knockout mice. The dataset was used to identify genotype-dependent differences in inflammatory, hypoxia-responsive, metabolic, and stress-related gene-expression pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE332879 | GEO | 2026/05/26

REPOSITORIES: GEO

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			Action	DRS
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	GSE332879_LRRC8A_VSMC_DESeq2_results.txt.gz	Txt
	GSE332879_LRRC8A_VSMC_normalized_counts.txt.gz	Txt
	GSE332879_LRRC8A_VSMC_raw_count.txt.gz	Txt

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