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MiRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE33338 | GEO | 2012/06/01

SECONDARY ACCESSION(S): PRJNA148963

REPOSITORIES: GEO

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miRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro

Project description:This SuperSeries is composed of the following subset Series: GSE33336: Development of microRNA expression signature for emphysema in COPD patients GSE33337: miRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro [target gene expression data] Refer to individual Series

2012-05-31 | E-GEOD-33338 | biostudies-arrayexpress

miRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro [target gene expression data]

Project description:To define the role of microRNAs and their mRNA targets in emphysema severity in COPD patients.

2012-06-01 | GSE33337 | GEO

miRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro [target gene expression data]

Project description:To define the role of microRNAs and their mRNA targets in emphysema severity in COPD patients. We performed Agilent human miRNA oligo arrays (8x15K array, Part No. G4470A, Agilent Technologies) based on miRBase V9.1 on lung tissues from 9 mild and 20 moderate emphysema lungs obtained from patients undergoing curative resection for lung cancer. We identified 5 miRNAs and two of those were tested and validated technically using qRT-PCR. The predicted mRNA targets for the five miRNAs were identified in MSigDB using GSEA and their expression were negatively correlated in exvivo lung mRNA expression profile obtained from GEO datasets (GSE17770 and GSE1650). Increasing the expression of one of the miRNA target, miR-34c in BEAS-2B and HFL 1 cell lines resulted in the downregulation of 50 TargetScan and Pictar predicted targets of miR-34c.

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miRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro

Project description:miRNA changes in mild and moderate emphysema correlate with target gene expression in vivo and in vitro

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Transcription profiling of human lung tissue from severe emphysema versus normal or mild emphysema human patients

Project description:Comparison of severely emphysematous tissue removed at lung volume reduction surgery to that of normal or mildly emphysematous lung tissue resected from smokers with nodules suspicious for lung cancer. Data obtained from the 18 patients with severe emphysema and 12 patients with mild/no emphysema. Research may provide insights into the pathogenetic mechanisms involved in chronic obstructive pulmonary disease (COPD).

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