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Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

ABSTRACT: This study aimed at characterizing the effect of the innate immune agonist, dsRNA, on ovarian cancer cell lines and ascites-derived ovarian cancer cells. DsRNA stimulation revealed two sub-populations of ovarian cancer cells, dsRNA sensitive and dsRNA resistant, that could be categorized based upon dsRNA-induced dsRNA receptor expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE33342 | GEO | 2012/04/29

SECONDARY ACCESSION(S): PRJNA148971

REPOSITORIES: GEO

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Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

Project description:This study aimed at characterizing the effect of the innate immune agonist, dsRNA, on ovarian cancer cell lines and ascites-derived ovarian cancer cells. DsRNA stimulation revealed two sub-populations of ovarian cancer cells, dsRNA sensitive and dsRNA resistant, that could be categorized based upon dsRNA-induced dsRNA receptor expression. Human ovarian cancer cell lines were treated with pI:pC and compared against untreated cells.

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