Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE334763 | GEO | 2026/06/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10x Xenium)

Project description:Natural killer (NK) cell–targeting immunotherapies are emerging, yet the differentiation and functional states of tumor-infiltrating NK cells remain poorly understood. Using matched single-nucleus RNA and ATAC sequencing of samples from patients with non–small cell lung cancer (NSCLC), we resolved the transcriptional and epigenetic landscape of intratumoral NK cells. We identified two tumor-associated NK (taNK) cell subsets marked by expression of ITGAE (CD103) and ITGA1 (CD49a) that display features of tissue residency and dysfunction while preserving cytotoxic function. Trajectory and regulon analyses revealed an inflammation-driven transition from early granzyme K (GZMK)+ NK cells toward an ENTPD1+ (CD39+) effector state characterized by interferon-stimulated gene (ISG) programs. Functional profiling established CD39+ taNK cells as the dominant cytotoxic NK cell population with superior killing capacity that was further potentiated by NKG2A blockade. This study offers mechanistic insights into NK cell differentiation in NSCLC and establishes CD39+ taNK cells as a targetable effector population for immunotherapy.

2026-06-05 | GSE319755 | GEO

Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10X Multiome)

2026-06-05 | GSE304741 | GEO

Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer

Project description:Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer

| PRJNA1476292 | ENA

Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10X Multiome)

Project description:Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10X Multiome)

| PRJNA1302431 | ENA

Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10x Xenium)

Project description:Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10x Xenium)

| PRJNA1425050 | ENA