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Differential chromatin accessability in follicular B cells, marginal zone B cells and newly formed plasma cells. [ATAC-Seq]

ABSTRACT: Marginal zozne B cells are poised to rapidly differentiate into plasma cells through biochemical pathways activated by Notch2 signaling. We sought to determine differences in chromatin accessability at plasma cell program-relevant loci between these cells and follicular B cells also located within the spleen but less receptive to Notch signaling. To ths end, we prepared ATAC-seq libriaries from steady state marginal zone and follicular B cells as well as newly formed plasma cells generated in Blimp1GFP/+ reporter mice 4 days post immunization with LPS.

ORGANISM(S): Mus musculus

PROVIDER: GSE335246 | GEO | 2026/07/08

REPOSITORIES: GEO

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