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MiRNA profiling data supporting “IL-4/C1q activated astrocyte-derived extracellular vesicles promote stroke infarct recovery by recruiting peripheral leukocytes”

ABSTRACT: This study aims to engineer an injectable biomaterial platform to promote brain repair post-stroke. We used extracellular vesicles derived from reactive astrocytes and decorated them onto the surface of hydrogel microparticles. Then they were injected into stroke cavity and crosslinked into porous scaffold in situ, which enabled persistent and uniform distribution of astrocyte-derived extracellular vesicles. Extracellular vesicles from reactive astrocytes activated with different cytokines showed different brain regeneration outcomes. IL-4/C1q activated astrocyte extracellular vesicles promoted robust angiogenesis within the stroke infarct and improved functional recovery significantly. These miRNA profiling data shows the different cargos of extracellular vesicles derived from untreated, IL-1α/TNFα/C1q, IL-4/C1q. We showed IL-4/C1q extracellular vesicles possessed adhesive miRNAs that recruited pro-reparative leukocytes and resulted in improved regeneration.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE335335 | GEO | 2026/07/10

REPOSITORIES: GEO

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miRNA profiling data supporting “IL-4/C1q activated astrocyte-derived extracellular vesicles promote stroke infarct recovery by recruiting peripheral leukocytes”

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