Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from mouse T-cell lymphomas

ABSTRACT: Transgenic expression of key transcritpion factors inducing T-cell leukemias in mice. We used microarrays to identify the gene expression signatures associated with TLX1transgenic /RUNX1 heterozygous tumors compared with different genetic models T acute lymphoblastic lymphoma.

ORGANISM(S): Mus musculus

PROVIDER: GSE33549 | GEO | 2011/11/08

SECONDARY ACCESSION(S): PRJNA154263

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data from mouse T-cell lymphomas

Project description:Transgenic expression of key transcritpion factors inducing T-cell leukemias in mice. We used microarrays to identify the gene expression signatures associated with TLX1transgenic /RUNX1 heterozygous tumors compared with different genetic models T acute lymphoblastic lymphoma. RNA extraction from T-cell tumors from mice with different T-cell lymphoma-predisposing genetic backgrounds.

2011-11-08 | E-GEOD-33549 | biostudies-arrayexpress

Expression data from mouse T-cell lymphomas

2010-10-19 | GSE19499 | GEO

Expression data from mouse T-cell lymphomas

Project description:Transgenic expression of TLX1 induces T-cell leukemias in mice. We used microarrays to identify the gene expression signatures associated with TLX1 tumors compared with different genetic models T acute lymphoblastic lymphoma. RNA extraction from T-cell tumors from mice with different T-cell lymphoma-predisposing genetic backgrouds.

2010-10-19 | E-GEOD-19499 | biostudies-arrayexpress

Genome-wide mapping of TEL-AML1 targets in acute leukemia

2015-12-31 | GSE67519 | GEO

B cell Lymphomas present Immunoglobulin Neoantigens

Project description:Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chromatography and tandem mass spectrometry (LC-MS/MS) to define antigens presented by follicular lymphomas (FL), chronic lymphocytic leukemias (CLL), diffuse large B cell lymphoma (DLBCL) and mantle cell lymphomas (MCL). We found presentation of the clonal immunoglobulin molecule, including neoantigens by both class I and class II MHC, though more commonly in class II MHC. To determine whether B cell activation could promote presentation of immunoglobulin neoantigens, we used a toll-like receptor 9 (TLR9) agonists to upregulate expression of MHC-II. This resulted in enhanced class II MHC presentation of the immunoglobulin variable region including neoantigens. These findings demonstrate that immunoglobulin neoantigens are presented across most subtypes of B cell lymphomas. Activation of lymphoma cells to upregulate antigen presentation boosts presentation of immunoglobulin neoantigens and represents a strategy for augmenting lymphoma immunotherapies.

2019-01-07 | PXD010808 | Pride

Illumina and Affymetrix SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples

Project description:This SuperSeries is composed of the following subset Series: GSE25102: Illumina SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples GSE25116: Affymetrix SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples Refer to individual Series

2012-07-02 | E-GEOD-25117 | biostudies-arrayexpress

e22f0dd5-e199-4b92-bb5c-3a5ae19c6cbf - samples

Project description:High-throughput transcriptome sequencing data from paediatric (<18-y) ETV6-RUNX1 fusion positive acute lymphoblastic leukemias. Dataset includes fastq and BAM files from diagnostic samples of 33 patients.

| EGAD00001010164 | EGA

Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas

Project description:This analysis compares the signal of DNA from T-cell lymphoblastic lymphomas induced by gamma-irradiation versus normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias

2008-06-26 | GSE10858 | GEO

Genome-wide mapping of TEL-AML1 targets in acute leukemia

Project description:Around 20-25% of childhood acute lymphoblastic leukemias carry the TEL-AML1 (TA) fusion gene. It is a fusion of two central hematopoietic transcription factors, TEL (ETV6) and AML1 (RUNX1). Despite its prevalence, the exact genomic targets of TA have remained elusive. We evaluated gene loci and enhancers targeted by TA genome-wide in precursor B acute leukemia cells using global nuclear run-on sequencing (GRO-seq). Nascent RNA expression profiles were generated with GRO-seq after TEL-AML1 expression in the Nalm6 pre-B-ALL cell line in four different time points (0, 4, 12 and 24 h). TEL-AML1-mut and luciferase induction cell lines were used as controls. Two replicates were included for all six samples.

2015-12-31 | E-GEOD-67519 | biostudies-arrayexpress

Inducible PAX5 expression in a human B lymphoblastic leukemia cell line

Project description:Hypomorphic mutations of the transcription factor PAX5 occur in one third of B-progenitor acute lymphoblastic leukemias (B-ALLs). To identify PAX5-regulated genes in B-ALL, here we employ inducible expression of PAX5 in a human B-ALL cell line (REH) that harbors a loss-of-function mutation in PAX5. In this model, inducing PAX5 expression is associated with competitive disadvantage.

2014-06-18 | GSE57480 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data