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SerpinA3 is an endogenous TGF-β receptor antagonist that attenuates cardiac fibroblast activation and fibrotic remodeling

ABSTRACT: Using a transverse aortic constriction (TAC) model, we observed that SerpinA3K expression was markedly reduced in failing mouse hearts and in circulation. Pharmacological supplementation or genetic augmentation of SerpinA3 markedly attenuated cardiac dysfunction and fibrotic remodeling in response to pressure overload. Single-cell transcriptomic analyses further demonstrated that SerpinA3 suppresses profibrotic fibroblast programs by promoting a transition from activated and extracellular matrix–producing fibroblasts toward a quiescent, pro-angiogenesis state.

ORGANISM(S): Mus musculus

PROVIDER: GSE335919 | GEO | 2026/09/02

REPOSITORIES: GEO

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