Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The resin glycoside Cus-1, a cuscutae extract, ameliorates oligozoospermia via an aquaporin-driven p38 MAPK/SAT1/GPX4 axis that suppresses ferroptosis and restores spermatogenesis

ABSTRACT: This study employed 1H-NMR-guided isolation to rapidly pinpoint, purify and elucidate the on-the-map metabolite resin glycosides“Cus-1” from the Cuscuta chinensis Lam. phenotype, and subsequently interrogated its remedial value in a busulfan (BUS)-induced mouse model of oligozoospermia.

ORGANISM(S): Mus musculus

PROVIDER: GSE336587 | GEO | 2026/06/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The resin glycoside Cus-1, a cuscutae extract, ameliorates oligozoospermia via an aquaporin-driven p38 MAPK/SAT1/GPX4 axis that suppresses ferroptosis and restores spermatogenesis

Project description:The resin glycoside Cus-1, a cuscutae extract, ameliorates oligozoospermia via an aquaporin-driven p38 MAPK/SAT1/GPX4 axis that suppresses ferroptosis and restores spermatogenesis

| PRJNA1482038 | ENA

Enterobacteria phage CUS-3

Project description:Integrated prophage CUS-3 from Escherichia coli RS218

| PRJNA19411 | ENA

Resin tapping transcriptome in adult slash pine (Pinus elliottii var. elliottii)

Project description:To better understand the molecular bases of resin production, a major source of terpenes for industry, the transcriptome of adult Pinus elliottii var. elliottii (slash pine) trees under field commercial resinosis was obtained.

2019-06-22 | GSE133168 | GEO

circRNA sequencing facilitates quantitative analysis of CUS mice hippocampus and Control mice hippocampus

Project description:The goal of this study is to seek the potential circular RNAs (circRNAs), which express differently between control group and chronic unpredictable stress (CUS) group mouse hippocampus, involved in major dipresssion disorder (MDD) by high-throughput sequencing. QPCR was preformed to identify the circRNAs trend. CircRNAs are a class of RNAs in the eukaryotic transcriptome. The function and explicit downstream mechanisms of circRNA regulated in maior depression disorser remain unclear. To further investigate the potential role of circRNAs in MDD, we performed human and mouse homology screening on circRNA sequences using the Basic Local Alignment Search Tool on the NCBI website. CircSTAG1, a homologous human and mouse circRNA, was found downregulated in circRNA high-throughput sequencing. Our study represents the first detailed analysis of circRNA expressing differently in CUS mouse hippocampus by high-throughput sequencing.

2022-08-02 | GSE135343 | GEO

Identification and characterization analysis of the different genes in CUS mouse treated with RVG-circDYM-EVs using RNA-seq.

Project description:Whole RNA-sequencing analysis was performed and analyzed by Lc. Biotech Co. Ltd. (Hangzhou, China). hippocampus tissue from the Ctrl + Ctrl group, Ctrl + circDYM group, CUS + Ctrl group, and CUS + circDYM group were collected in TRIzol. Total RNAs were extracted from Trizol. UMI technology was used to label each sequence fragment with sequence tags, which minimized the interference of duplication caused by PCR amplification on the quantitative accuracy of the transcriptome. RNA sequencing reads were aligned to the mouse genome (GRCh37/hg19) using the software Hisat2 (2.0.4). Transcript abundance was evaluated by calculating fragments per kilo base of exon per million fragments mapped (FPKM).

2023-11-11 | GSE189273 | GEO

Advancing DNA extraction from experimental resin-preserved specimens

Project description:Advancing DNA Extraction from Resin-Preserved Specimens

| PRJEB88184 | ENA

Expression data from the liver of rat treated by Piperonyl butoxide and Dammar resin

Project description:Several studies have successfully detected hepatocarcinogenicity in rats based on gene expression data. Here, we constructed a model for detecting non-genotoxic (NGTX) hepatocarcinogens and predicted their MOAs in rats. Piperonyl butoxide (PBO) and Dammar resin (DAM) are NGTX hepatocarcinogens. Gene expression data in the liver treated by PBO and DAM was used for validation of constructed model.

2015-07-29 | GSE71413 | GEO

RNA-sequencing of gastric cancer PDX mice model after treated with CUS

Project description:The interaction between cancer and depressive disorder remains unclear. In this study, we obtained patient data from TCGA and MDD-related (Major Depressive Disorder) genes from the GEO database and the sequencing data of the PDX model with chronic unpredictable stress (CUS). Molecular subtypes and a prognostic signature were generated based on the MDD-related genes obtained by differential expression analysis. According to our analysis, the gene signature was a promising biomarker in distinguishing the prognosis, the molecular or immune characteristics, and the depressive risk, as well as the therapy candidates for gastric adenocarcinoma patients.

2024-07-19 | GSE262056 | GEO

Yttrium Y 90 Resin Microspheres Data Collection in Unresectable Liver Cancer: the RESIN Study

Project description:This research registry studies Yttrium Y 90 resin microspheres in collecting data from patients with liver cancer not capable of being removed by surgery (unresectable) for the radiation-emitting Selective Internal Radiation-Spheres (SIR-spheres) in non-resectable (RESIN) liver tumor registry. The information generated will help doctors better understand treatment patterns involving Y90 therapy, gain additional insights in the long-term outcomes for patients, as well as guide future research for using Y90 therapy, especially for those conditions where data is currently very limited or lacking.

| 2208508 | ecrin-mdr-crc

Molecular mechanism of Forsythia suspensa glycoside promoting innate immunity by activating ER stress.

Project description:Forsythia suspensa glycoside is a phenylethanoid glycoside extracted from the bark, leaves, flowers, fruits, and seeds of the Oleaceae plant Forsythia suspensa. As a major active ingredient in the Chinese herbal medicine Forsythia suspensa, it has a wide range of pharmacological activities. It not only inhibits various Gram positive and negative bacteria that cause infections, but also has strong antiviral effects. However, the role of Forsythia suspensa glycosides in innate immunity is not yet clear.

2026-01-01 | GSE275102 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data