Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology [scRNAseq-human]

ABSTRACT: Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS pathogenesis remains elusive. Herein, we identified a functional thymus-ovary axis involved in PCOS development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE336823 | GEO | 2026/07/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology [scRNAseq-mouse]

Project description:Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS pathogenesis remains elusive. Herein, we identified a functional thymus-ovary axis involved in PCOS development.

2026-07-03 | GSE336822 | GEO

Proteome of follicular Fluid from lean and overweight/obese women with PCOS and that of healthy controls

Project description:Polycystic ovary syndrome (PCOS) is typically characterized by oligo or anovulation, hyperandrogenism and polycystic ovarian morphology, affecting 5-20% of women of reproductive age [1]. It has drawn significant attention as a major cause of anovulatory infertility and the syndrome of metabolic, reproductive and obstetrical disorders [2 ,+]. Due to heterogeneous clinical features and unclear pathogenesis of PCOS, the diagnosis and treatment strategies remain a matter of debate. To better understand the complex follicular development environment in PCOS, we conducted a TMT-based quantitative proteomic study to compare the composition of proteins, pathways and molecular functions of FF from lean and overweight/obese women with PCOS and that of healthy controls.

2019-10-31 | PXD013937 | Pride

Expression profiles of human cumulus cells from patients with PCOS and non-PCOS

Project description:To reveal mRNAs expression differences in cumulus cells between polycystic ovary syndrome (PCOS) and non-PCOS women. mRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS were determined by Illumina Novaseq 6000.

2024-10-30 | GSE277906 | GEO

miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS

2015-04-28 | GSE68285 | GEO

miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS

Project description:To reveal microRNAs expression differences in cumulus cells between polycystic ovary syndrome (PCOS) and non-PCOS women. miRNAs expression profile of the cumulus cell samples with PCOS and non-PCOS were determined by Affymetrix miRNA 2.0. Six pooled RNAs from CC samples (three PCOS and three non-PCOS pooled RNAs) were separately analyzed on 6 GeneChip miRNA 2.0 Array (miRBase V15)

2015-04-28 | E-GEOD-68285 | biostudies-arrayexpress

Mogrosisde V improves follicular development and ovulation in PCOS rats induced by letrozole and high-fat diet through promoting glycolysis

Project description:Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. In this study, we induced a PCOS rat model by oral administration of letrozole combined with a high-fat diet and then treated with mogroside V (MV) to evaluate the protective roles on endocrine and follicle development in PCOS rats and the underlying mechanisms. Purpose: To detect the difference of ovary transcriptome profiling between PCOS model and Control rat and to evaluate the effect of mogroside V on the transcriptome profiling of ovaries of PCOS model rats. Methods: Ovarian mRNA profiles of 15-week-old Control, PCOS and PCOS-MV group rats (4 rats per group) were generated by deep sequencing,using Illumina PE150.

2022-04-20 | GSE194398 | GEO

Adrenarche in the spiny mouse (Acomys dimidiatus) reveals effects of prepubertal DHEA on the reproductive axis and PCOS-like phenotypes

Project description:Adrenarche, characterized by rising adrenal dehydroepiandrosterone (DHEA) levels, precedes puberty and has been implicated in reproductive maturation, and disorders like polycystic ovary syndrome (PCOS). However, the mechanisms by which DHEA influences the hypothalamic-pituitary-gonadal (HPG) axis remain poorly understood, largely due to the absence of an appropriate animal model. The spiny mouse (genus Acomys), which has a prolonged juvenile phase and endogenous prepubertal DHEA production, provides a valuable system to investigate the effects of early-life exposure to DHEA. We confirmed the spiny mouse prepubertal rise in circulating DHEA levels, which occurs independently of HPG axis activation. Transcriptomic analysis revealed increased ovarian expression of steroidogenic and estrogen-responsive genes, suggesting possible effects of DHEA. We show in vitro that DHEA induces Prlr and Prl expression seemingly via the estrogen receptor. Adrenalectomy (Adx) followed by DHEA “rescue” (AdxDHEA) revealed that DHEA can be synthesized and metabolized outside the adrenal glands. Ovarian transcriptomes from AdxDHEA mice exhibited extensive changes, including upregulation of immune response-related genes, and downregulation of cholesterol-metabolism and estrogen-synthesis genes, most notably Cyp19a1. The reduced Cyp19a1 expression is likely due to elevated Amhr2, and was accompanied by a high androgen-to-estrogen ratio, indicating a DHEA-induced, PCOS-like phenotype. The rise in DHEA during an extended juvenile phase establishes the spiny mouse as a suitable model for studying the consequences of elevated DHEA in childhood. Our findings reveal that prepubertal exposure to DHEA alters ovarian gene expression and steroidogenesis, providing mechanistic insight into how early androgen excess may predispose to reproductive dysfunction.

2026-05-14 | GSE306393 | GEO

Spatial Transcriptomics Reveals Inhba/Smad2/E2f4 Axis in Lrp2high Thecal Cell Proliferation in Androgen-Induced PCOS Mice

Project description:Hyperandrogenemia is a primary character of polycystic ovary syndrome (PCOS), a leading cause of woman infertility. As a source of androgen secretion, thecal cells (TC) exhibit hyperplasia in the ovarian of PCOS conditions providing a potential mechanism for hyperandrogenemia. However, the molecular events driving TC hyperproliferation are not fully elucidated. In this study, we employed spatial transcriptomics investigating the ovarian of a mouse PCOS model induced by dehydroepiandrosterone (DHEA). Substantial alteration was observed in gene expression across multiple cell types in the ovarian, and a dramatic expansion was observed in Lrp2high subpopulation of TC. Functional analysis of gene interaction led to identification of the Inhba/Smad2/E2f4 pathway in the hyperproliferation of Lrp2high subset. Knockdown of any gene in the pathway led to suppression of TC proliferation, with a dominant impact upon Inhba inactivation. These results suggest that the Inhba/Smad2/E2f4 axis may be responsible for TC over proliferation in PCOS and a potential therapeutic target in the control of PCOS.

2025-08-27 | GSE296728 | GEO

Identification of microRNA profiling of human ovary in PCOS with insulin resistance (pilot study)

Project description:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It has become increasingly evident that insulin resistance plays a significant role both as a cause and result of the syndrome. In an effort to investigate further the observed insulin resistance in the ovarian tissue of women with PCOS, we conducted array-based, global miRNA profiling.

2015-01-12 | GSE28832 | GEO

Identification of microRNAs involved in polycystic ovary syndrome based on High-throughput sequencing [miRNA-seq]

Project description:Aberration in miRNA expression or DNA methylation is a causal factor for numerous pathological conditions including polycystic ovarian syndrome PCOS, a common endocrine disorders and leading cause of infertility. The epigenetic interactions between miRNA and DNA methylation remain unexplored in PCOS. Few studies have reported that the regulation of miRNAs in polycystic ovary syndrome(PCOS). Our study helps to understand the molecular pathogenesis of PCOS in human ovarian granulosa cells from the perspective of post-transcriptional level.

2019-10-09 | GSE138572 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data