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Transcriptome-wide m6A methylation profiling of penile tissues in a rat model of hypospadias

ABSTRACT: RNA modifications are an important component of epigenetic regulation and play essential roles in embryonic development. Among these modifications, N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNA, regulates diverse physiological and pathological processes. Increasing evidence suggests that dysregulated m6A methylation contributes to congenital malformations and reproductive system disorders. In this study, methylated RNA immunoprecipitation sequencing (MeRIP-seq) was performed on penile tissues collected from normal rats and a rat model of hypospadias to characterize the transcriptome-wide m6A methylation landscape associated with hypospadias. These data provide a resource for investigating the potential role of m6A RNA methylation in the molecular mechanisms underlying hypospadias.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE337280 | GEO | 2026/07/06

REPOSITORIES: GEO

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