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Whole transcriptome analysis of salivary glands from the salivary glands of NIH COVID-19 autopsies

ABSTRACT: Salivary glands are recognised targets of SARS-CoV-2 infection, with viral RNA and protein detected in both major and minor glandular tissue; however, the transcriptional response of salivary gland epithelium and stroma to infection remains poorly characterised. Here, we present a bulk RNA sequencing dataset from major (parotid, submandibular) and minor salivary gland samples obtained at autopsy from individuals with confirmed COVID-19 and controls. Transcriptomic profiling reveals dysregulated innate immune signalling, interferon response pathways, or glandular epithelial stress responses in COVID-19 compared to control tissue, with differences observed between both major and minor gland compartments; gland-specific features were identified. These data provide a tissue-level transcriptional resource for investigating salivary gland pathology in acute COVID-19 and its potential contribution to oral manifestations of infection and post-acute sequelae. Manuscripts to site: Huang N, Pérez P,...Warner BM, Byrd KM. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med. 2021 May;27(5):892-903. doi: 10.1038/s41591-021-01296-8. Epub 2021 Mar 25. PMID: 33767405; PMCID: PMC8240394; Stein SR, ...et al., ...Hewitt SM, Kleiner DE, Chertow DS. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature. 2022 Dec;612(7941):758-763. doi: 10.1038/s41586-022-05542-y. Epub 2022 Dec 14. PMID: 36517603; PMCID: PMC9749650.

ORGANISM(S): Homo sapiens

PROVIDER: GSE337369 | GEO | 2026/08/10

REPOSITORIES: GEO

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