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The spatial transcriptomics of the mouse brain 3 days after tMCAO

ABSTRACT: This study employed spatial transcriptomics to profile the expression and spatial distribution of Htr2b, P2ry12, Mrc1, and Ms4a7 in mouse brains 3 days after transient middle cerebral artery occlusion (tMCAO). By capturing genome‑wide transcriptional data with spatial coordinates, we aimed to map the regional expression patterns of these genes across the ischemic core, penumbra, and remote areas, and to delineate their co‑localization relationships with distinct immune and glial cell populations. This spatially resolved approach will provide insights into the topographic organization of serotonergic signaling and neuroimmune interactions during the acute phase of ischemic stroke.

ORGANISM(S): Mus musculus

PROVIDER: GSE337578 | GEO | 2026/07/09

REPOSITORIES: GEO

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