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ScRNA-seq data for nonunion fracture

ABSTRACT: This single-cell RNA-seq dataset profiles clinical fracture-healing tissues from patients with fracture nonunion and normally healed fracture controls. Eight human specimens were initially collected, including five fracture nonunion samples and three normally healed control samples. After quality-control and integration assessment, two nonunion samples (NUBF01 and NUBF03) were excluded from the final integrated analysis because of marked batch-related interference; the final analyzed dataset comprised three nonunion samples (NUBF02, NUBF04, NUBF05) and three control samples (G0531, G0601, G0607). Cell-cell communication analysis prioritized fibroblast-to-osteoblast signaling and highlighted an enhanced LIF-(LIFR+IL6ST) interaction in nonunion tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE337700 | GEO | 2026/07/10

REPOSITORIES: GEO

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