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Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila

ABSTRACT: This study investigates whether adult tissue aging trajectories are established early during development by genetically modulating cellular aging pathways in Drosophila larval adult midgut progenitors (AMPs)—the precursors to adult intestinal stem cells. Bulk transcriptomic analysis reveals that accelerating larval AMP aging via immune overactivation (Toll/Imd) or elevated reactive oxygen species (ND42 knockdown) causes long-term adult consequences, including disrupted progenitor architecture, genomic instability, epithelial barrier failure, and skewed lineage allocation towards enteroendocrine cells. Conversely, decelerating larval AMP aging via Foxo or Atg8a overexpression protects adult intestinal barrier integrity, demonstrating that early-life developmental programming in AMPs tightly dictates the long-term trajectory and homeostasis of the adult gut.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE337803 | GEO | 2026/08/19

REPOSITORIES: GEO

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Anti-tumor effects of antimicrobial peptides, targets of the innate immune system, against hematopoietic tumors in Drosophila mxc mutants

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