Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Vascular function underlies enhanced intestinal regeneration after FLASH radiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE338640 | GEO | 2026/07/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Vascular function underlies enhanced intestinal regeneration after FLASH radiation [scRNAseq]

Project description:Ultra-high dose-rate FLASH radiotherapy spares normal tissue while promoting tumor control, yet the basis of this protection remains unknown. Using whole-abdominal irradiation, intestinal organoids, single-cell transcriptomics, spatial vascular phenotyping, and genetic, pharmacological, and physiological perturbations, we show that the intestinal FLASH effect is the result of active heterotypic vascular-epithelial crosstalk rather than passive radiochemical protection. FLASH preserves endothelial tone and perfusion along the crypt–villus axis, averting phospho-MLC–dependent vascular collapse caused by conventional irradiation. This maintains the physiological oxygen gradient and licenses early, YAP-dependent regeneration that shields transit-amplifying secretory progenitors from persistent DNA damage and drives rapid crypt reconstitution. Disrupting the oxygen gradient directly, or indirectly through endothelial VEGFR2 blockade, abolishes FLASH sparing—reinstating progenitor DNA damage, loss of DCLK1⁺ and CHGA⁺ cells, and impaired regeneration. We identify an oxygen–vasculature–YAP–progenitor axis as a central regulator of radiation-induced repair and a target to widen the therapeutic window.

2026-07-17 | GSE338639 | GEO

Vascular function underlies enhanced intestinal regeneration after FLASH radiation [bulk RNAseq]

2026-07-17 | GSE337790 | GEO