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The role of GLS1 and MPC2 in germinal center B cell regulation

ABSTRACT: The efficiencies with which activated B lymphocytes proliferate and develop into antibody (Ab)-secreting plasma cells are critical determinants of adaptive humoral immunity and central to sustaining certain autoimmune diseases. Increasing evidence indicates that specific pathways in intermediary metabolism, or their substrate supply, influence lymphocyte differentiation and function. To investigate the role of glutaminolysis by GLS1 and mitochondrial pyruvate import via MPC2 on germinal center B cell differentiaiton and function flow-purified we immunized wild-type, GLS1-KO, MPC2-KO, or double KO mice with SRBC and FACS isolated germinal center B cells after 7 days for transcriptional profiling.

ORGANISM(S): Mus musculus

PROVIDER: GSE338789 | GEO | 2026/07/30

REPOSITORIES: GEO

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The role of glutaminolysis and mitochondrial pyruvate import on plasma cell differentiation

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