Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dysregulation of c-terminal ezrin phosphorylation prevents tumor progression and metastasis and alters cellular metabolism in osteosarcoma

ABSTRACT: This dataset contains Affymetrix Mouse Genome 430 2.0 Array data obtained from K7M2 cells over-expressing ezrinT567A and the wild-type

ORGANISM(S): Mus musculus

PROVIDER: GSE33897 | GEO | 2012/03/14

SECONDARY ACCESSION(S): PRJNA148255

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Dysregulation of c-terminal ezrin phosphorylation prevents tumor progression and metastasis and alters cellular metabolism in osteosarcoma

Project description:This dataset contains Affymetrix Mouse Genome 430 2.0 Array data obtained from K7M2 cells over-expressing ezrinT567A and the wild-type Gene expression analysis of K7M2 cells over-expressing ezrinT567A compared to the wild-type

2012-03-14 | E-GEOD-33897 | biostudies-arrayexpress

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.

Project description: Not available

| S-EPMC3867810 | biostudies-literature

RNA sequencing of murine osteosarcoma tumors

Project description:We utilized murine osteosarcoma cell lines F420 and K7M2. F420 was originally derived from a female C57BL/6 mouse transgenic for a mutant p53 under control of a bone-selective promoter (PMID: 25579177). K7M2 was derived from a spontaneous metastatic lesion in a female Balb/C background (PMID: 16837208). F420 osteosarcoma tumors were established by subcutaneously injecting 5 x 10^6 osteosarcoma cells into the flanks of 6-week-old C57BL/6 mice (Envigo, Frederick, MD). K7M2 tumors were established by transplanting small pieces of sectioned tumor (~2mm3) into the flanks of 6-week-old Balb/C mice (Envigo). We found K7M2 to be more immunogenic than F420 as it demonstrated higher immune cell infiltrates, higher expression of immune-related genes, and slower growth in syngeneic versus nude models.

2021-06-29 | GSE166282 | GEO

Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma.

Project description: Not available

| S-EPMC3119000 | biostudies-literature

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.

Project description: Not available

| S-EPMC7213760 | biostudies-literature

Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells.

Project description: Not available

| S-EPMC3372425 | biostudies-literature

LC-MS/MS of extracellular vesicles from murine osteosarcoma cell line K7 and K7M2

Project description:Extracellular vesicles have been shown to be highly enriched in proteins with various functions, including organotropic metastasis. To identify possible protein cargos involved in regulating mestastatic potential of osteosarcoma cell line, we performed quantitative mass spectrometry analysis of EVs from highly metastatic K7M2 cells and poorly metastatic parental K7 cells.

2024-01-15 | PXD035216 | Pride

Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.

Project description: Not available

| S-EPMC2785675 | biostudies-literature

Role of Ezrin Phosphorylation in HIV-1 Replication.

Project description: Not available

| S-EPMC6119696 | biostudies-literature

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma.

Project description: Not available

| S-EPMC4349528 | biostudies-literature