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Characterizing the tumor microenvironment at the single-cell level reveals the potential immune evasion mechanism in giant cell tumor of bone

ABSTRACT: Giant cell tumor of bone (GCTB) is intermediate, locally aggressive primary bone tumor that are usually occur in long bones and typically present as lytic lesions, leading to cortical expansion or destruction with a soft-tissue component. At present, the main treatment of GCTB is surgical curettage and bone cement filling, but the recurrence rate is more than 20%. It is known that tumor recurrence and immune escape are closely related to the microenvironment. We need a deeper understanding of the complex tumor microenvironment, as well as the role of various immune cells in the development of GCTB, in order to achieve a comprehensive treatment of GCTB.

ORGANISM(S): Homo sapiens

PROVIDER: GSE341436 | GEO | 2026/07/31

REPOSITORIES: GEO

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