Effects of maternal trace mineral injection 114 days prepartum on offspring liver transcriptome

ABSTRACT: The objective of this study was to evaluate the effects of a prepartum trace mineral injection (TMI) in Brangus cows on growth, physiology, and the liver transcriptomic profile of their offspring. At 114 days prepartum (day –114), 40 cows were assigned to: 1) Saline (SAL solution; 0.9% NaCl; n = 20) or 2) TMI (solution containing 60, 10, 5, and 15 mg/mL of Zn, Mn, Se, and Cu, respectively; n = 20) administered subcutaneously [1 mL/90 kg of body weight (BW)] in each cow. Cow-calf collections were conducted until weaning (day 234), and no treatment solutions were applied in calves. TMI did not affect (P ≥ 0.11) BW, body condition score, liver mineral concentration, other serum biochemistry variables, and serum insulin in cows. The BW tended to be greater (P = 0.10) on days 80 and 157 in TMI vs Saline calves. Liver genes related to immune response were differently expressed (P-value ≤ 0.05) in TMI vs Saline calves. Thus, prepartum TMI tended to increase BW, affect circulating metabolite concentrations, and alter liver gene expression associated with the immune system in the offspring.

ORGANISM(S): Bos taurus

PROVIDER: GSE342538 | GEO | 2026/09/02

REPOSITORIES: GEO