High-altitude hypoxia suppresses triple-negative breast cancer growth by regulating ferroptosis via PHD2

ABSTRACT: High-altitude hypoxia may alter triple-negative breast cancer progression, but the underlying mechanisms remain incompletely understood. This study profiled transcriptomic changes in subcutaneous 4T1 tumors from female BALB/c mice maintained under ambient-altitude conditions in Lanzhou (approximately 1,500 m) or in a hypobaric chamber simulating an altitude of 3,500 m and treated with vehicle or the prolyl hydroxylase inhibitor IOX2. RNA sequencing data from 12 tumors were analyzed to identify changes associated with altitude exposure and PHD inhibition. Differential expression and Kyoto Encyclopedia of Genes and Genomes analyses indicated ferroptosis-related transcriptomic alterations, supporting further evaluation of the SLC7A11-GSH-GPX4/ACSL4 axis.

ORGANISM(S): Mus musculus

PROVIDER: GSE343905 | GEO | 2026/08/15

REPOSITORIES: GEO