Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatial transcriptomic profiling of calcified human coronary artery lesions

ABSTRACT: This study characterized spatial gene-expression patterns in calcified human coronary artery tissue using the 10x Genomics Visium CytAssist workflow.

ORGANISM(S): Homo sapiens

PROVIDER: GSE344969 | GEO | 2026/09/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptional profiling of osteogenic medium calcified human primary coronary artery smooth muscle cells.

Project description:Transcriptomics analysis of human coronary artery smooth muscle cells cultured in osteogenic medium (OM) to induce a mineralized extracellular matrix. To study the underlying molecular mechanisms driving vascular calcification, we analyzed the transcriptome of osteogenic medium (OM)-calcified human coronary artery smooth muscle cells on day 7.

2022-09-18 | GSE211722 | GEO

Transcriptional profiling of calcium-phosphate calcified human primary coronary artery smooth muscle cells.

Project description:Transcriptomics analysis of human coronary artery smooth muscle cells cultured in calcium-phosphate medium (CaP) to induce a mineralized extracellular matrix. To study the underlying molecular mechanisms driving vascular calcification, we analyzed the transcriptome of calcium-phosphate calcified human cronary aortic smooth muscle cells on day 3.

2022-09-18 | GSE211720 | GEO

Transcriptional profiling of calcifying human primary coronary artery smooth muscle cells

Project description:Transcriptomics analysis of human coronary artery smooth muscle cells cultured in osteogenic medium and PIKfyve inhibition. To study the underlying molecular mechanisms of PIKfyve-mediated vascular calcification, we analyzed the transcriptome of osteogenic medium (OM)-calcified human coronary artery smooth muscle cells that were treated with PIKfyve inhibitors (Apilimod, YM201636) or DMSO control on day 7.

2025-12-31 | GSE284683 | GEO

Transcriptional profiling of osteogenic medium calcified human primary coronary artery smooth muscle cells.

Project description:Transcriptional profiling of osteogenic medium calcified human primary coronary artery smooth muscle cells.

| PRJNA871892 | ENA

Transcriptional profiling of calcium-phosphate calcified human primary coronary artery smooth muscle cells.

Project description:Transcriptional profiling of calcium-phosphate calcified human primary coronary artery smooth muscle cells.

| PRJNA871890 | ENA

CD14 Serves as a Predicted Marker for Coronary Artery Lesions in Kawasaki Disease

Project description:Kawasaki Disease (KD) is an acute vasculitis that commonly occurs in younger children, which can lead to coronary artery aneurysm, dilatation and other severe cardiovascular diseases. However, the mechanism of coronary artery lesions remains unclear. In this study, we detected the mRNA expression profile of KD patients in the acute and subacute stages in the coronary artery lesions group (KD-CALs) and the non-coronary artery lesions group (KD-nCALs). 62 differentially expressed genes were found in the CALs group, and the differential genes were enriched in immune-related signaling pathways, significantly in the NF-kappa B signaling pathway. CD14-mRNA was confirmed to be down-regulated in the subacute stage of KD-CALs. Moreover, the downregulation of CD14 caused a decrease in the expression of a series of downstream genes such as IκBα, A20, and A1/Bf1_1. But only the downregulation of IκBα was in sync with CD14. In conclusion, CD14-mRNA was differentially expressed in the KD-CALs group and regulated the expression of IκBα via the NF-kappa B signaling pathway, finally inducing vascular endothelial cell injury. It can be served as a predicted marker for coronary artery lesions in KD. Besides, CD14 could become a potential therapy target for KD, especially in reversing coronary artery lesions (CALs).

2026-06-27 | GSE237851 | GEO

LncRNA expression profiling for 6 human monocytes samples from Coronary Artery Disease patients and non Coronary Artery Disease patients

Project description:The human LncRNA microarray analysis of the 6 monocytes samples from Coronary Artery Disease patients and non Coronary Artery Disease 3 Coronary Artery Disease patients and 3 non-Coronary Artery Disease donors

2015-06-05 | E-GEOD-69587 | biostudies-arrayexpress

LncRNA expression profiling for 6 human monocytes samples from Coronary Artery Disease patients and non Coronary Artery Disease patients

Project description:The human LncRNA microarray analysis of the 6 monocytes samples from Coronary Artery Disease patients and non Coronary Artery Disease

2015-06-05 | GSE69587 | GEO

LncRNA expression profiling for 6 human plasma samples from Coronary Artery Disease patients and non Coronary Artery Disease patients

Project description:The human LncRNA microarray analysis of the 6 plasma samples from Coronary Artery Disease patients and non Coronary Artery Disease

2015-05-05 | GSE68506 | GEO

Human coronary artery study

Project description:Study of atherosclerosis using 51 human coronary artery segments Keywords: other

2005-06-30 | GSE2143 | GEO