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Tie-2 expressing monocytes (TEM) expression data

ABSTRACT: TEM differentiated in vitro were exposed to treatments increasing or decreasing their proangiogenic activity. We used microarrays to identify the genes differentially expressed among the treatments and associated to changes in TEM proangiogenic and protumoral functions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE34559 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA151527

REPOSITORIES: GEO

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Tie-2 expressing monocytes (TEM) expression data

Project description:TEM differentiated in vitro were exposed to treatments increasing or decreasing their proangiogenic activity. We used microarrays to identify the genes differentially expressed among the treatments and associated to changes in TEM proangiogenic and protumoral functions. TEM were exposed 2 hours to the treatments, washed, kept for 30h in culture and used for RNA extraction.

2013-12-31 | E-GEOD-34559 | biostudies-arrayexpress

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer.

Project description: Not available

| S-EPMC4801424 | biostudies-literature

Transcription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells

Project description:Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry. We demonstrate that TCM have a gene expression and cytokine signaling signature that lies between that of TN and TEM or TEMRA cells, whereas TEM and TEMRA are closely related. Our data define the molecular basis for the different functional properties of central and effector memory subsets. We show that TEM and TEMRA cells strongly express genes with known importance in CD8 T cell effector function. In contrast, TCM are characterized by high basal and cytokine-induced STAT5 phosphorylation, reflecting their capacity for self-renewal. Altogether, our results distinguish TCM and TEM/TEMRA at the molecular level and are consistent with the concept that TCM represent memory stem cells.

2005-01-01 | E-TABM-40 | biostudies-arrayexpress

Transcriptomic evaluation of CD4+CD62L-CD44+FoxP3-CD45RbLo (RbLo TEM) versus CD4+CD62L+CD44-FoxP-CD45RbHi (RbHi TN) cells following activation

Project description:Deep sequencing of splenic RbLo TEM and RbHi TN cells 72 hours following anti-CD3 stimulation.

2019-06-10 | GSE89241 | GEO

T cell receptors repertoire sequencing of the human CD8+ memory subsets (Tstem, Tpex and TEM)

Project description:The data corresponds to the analysis of T cell receptor (TCR) repertoires of FACS-purified Tstem, Tpex and TEM cells of six individuals. The analysis of the TCR beta chain (TRB) demonstrated the differences between Tstem and Tpex repertoire properties. In total, 36 samples were analyzed using the Human TCR Profiling Kit (MiLaboratory LLC) for sequencing libraries preparation and Illumina NextSeq 550 sequencing (150+150bp) followed by the demultiplexing procedure using MIGEC software.

2020-08-01 | E-MTAB-8892 | biostudies-arrayexpress

Evaluation of transcriptional changes following stimulation of naïve, TCM, TEM and TEMRA CD8+ T cell subsets with AB248 compared to IL-2

Project description:Evaluation of transcriptional changes following stimulation of naïve, TCM, TEM and TEMRA CD8+ T cell subsets confirmed that AB248 recapitulated the expected IL-2 signature with high fidelity

2024-04-02 | GSE243601 | GEO

STAT1 and STAT3 ChIP-seq for naive and effector memory (Tem) CD4 T-cells after IL-6 treatment

Project description:Naïve and activated T-cells has a different response to antigenic challenge. We examine whether a cytokine like IL-6 induces different responses through the Jak-STAT pathway to affect the functional characteristics of a given CD4 T‑cell subset. We isolated naïve and effector memory (Tem) CD4 T-cells to investigated STAT1 and STAT3 binding after 1-hour treatment with 20ng/ml IL-6 in the presence of anti-CD3/CD28.

2019-02-08 | E-MTAB-6273 | biostudies-arrayexpress

E. coli MG1655-TEM-1 ceftazidime resistance evolution

Project description:Experimental evolution of ceftazidime resistance in MG1655 with and without TEM-1 on a plasmid or inserted into the chromosome.

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Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer.

Project description: Not available

| S-EPMC3433422 | biostudies-literature

Effect of anti-IL-15 administration on T cell and NK cell homeostasis in rhesus macaques (TEM)

Project description:Analysis of the effect of anti-IL-15 monoclonal antibody treatment on T cell and NK cell homeostasis in rhesus macaques. The hypothesis tested in the present study was that repeated administrations of a rhesusized anti-IL-15 monoclonal antibody would block IL-15 activity in vivo and result in changes to T and/or NK cell population dynamics that would reflect physiologic IL-15 function. The results provide important information on the specific role IL-15 plays in effector memory T cell and NK cell homeostasis, noting that effector memory T cells but not NK cells can be maintained in the absence of IL-15 signaling by the activity of other cytokines. Sort-purified CD8+ TEM from PBMC, before and after treatment with IgG1 Ab and anti-IL15 Ab

2016-09-07 | E-GEOD-76796 | biostudies-arrayexpress

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