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Elk1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer

ABSTRACT: Elk1 directs selective gene induction that is a substantial and critical component of growth signaling by AR in PC cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE34589 | GEO | 2013/05/02

SECONDARY ACCESSION(S): PRJNA150495

REPOSITORIES: GEO

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Elk1 Directs a Critical Component of Growth Signaling by the Androgen Receptor in Prostate Cancer

Project description:Elk1 directs selective gene induction that is a substantial and critical component of growth signaling by AR in PC cells. Gene expression in LNCaP cells was determined in androgen-depleted medium in response to R1881 in ELK1 knock down (via AR shRNA) or in cells treated with control shRNA.

2013-05-02 | E-GEOD-34589 | biostudies-arrayexpress

The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells.

Project description:The androgen receptor (AR) is essential for diverse aspects of prostate development and function. Molecular mechanisms by which prostate cancer (PC) cells redirect AR signaling to genes that primarily support growth are unclear. A systematic search for critical AR-tethering proteins led to ELK1, an ETS transcription factor of the ternary complex factor subfamily. Although genetically redundant, ELK1 was obligatory for AR-dependent growth and clonogenic survival in both hormone-dependent PC and castration-recurrent PC cells but not for AR-negative cell growth. AR required ELK1 to up-regulate a major subset of its target genes that was strongly and primarily enriched for cell growth functions. AR functioned as a coactivator of ELK1 by association through its A/B domain, bypassing the classical mechanism of ELK1 activation by phosphorylation and without inducing ternary complex target genes. The ELK1-AR synergy per se was ligand-independent, although it required ligand for nuclear localization of AR as targeting the AR A/B domain to the nucleus recapitulated the action of hormone; accordingly, Casodex was a poor antagonist of the synergy. ELK3, the closest substitute for ELK1 in structure/function and genome recognition, did not interact with AR. ELK1 thus directs selective and sustained gene induction that is a substantial and critical component of growth signaling by AR in PC cells. The ELK1-AR interaction offers a functionally tumor-selective drug target.

| S-EPMC3630885 | biostudies-other

ELK1 ChIP-seq

Project description:ELK1 ChIP-seq

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Small molecular ALA targets ELK1 to balance human neutrophil and erythroid differentiation

Project description:Alpha lipoic acid is reported to inhibit neutrophil lineage determination by targeting transcription factor ELK1 in granulocyte-monocyte progenitors. Here, we provide new evidence of alpha lipoic acid in promoting erythroid differentiation by targeting transcription factor ELK1 in CD34+CD371– hematopoietic stem progenitor cells. Over expression of both L-ELK1 and S-ELK1 greatly inhibit erythroid cell differentiation, but not knocking down of ELK1. Thus, RNAseq of CD34+CD123+CD38+CD371– HSPCs is performed to dissect the molecular mechanism of ELK1 in blocking erythrocyte differentiation.

2023-06-01 | GSE217887 | GEO

Elk1

Project description:Rattus norvegicus Elk1, ETS transcription factor ELK1 [Source:RGD Symbol;Acc:1598663], is differentially expressed in 12 experiment(s);

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Project description:Rattus norvegicus Elk1, ETS transcription factor ELK1 [Source:RGD Symbol;Acc:1598663], is expressed in 5 baseline experiment(s);

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Project description:Oryctolagus cuniculus ELK1, ETS transcription factor ELK1 [Source:HGNC Symbol;Acc:HGNC:3321], is expressed in 1 baseline experiment(s);

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Project description:Homo sapiens ELK1, ETS transcription factor ELK1 [Source:HGNC Symbol;Acc:HGNC:3321], is expressed in 43 baseline experiment(s);

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Project description:Anolis carolinensis ELK1, ETS transcription factor ELK1 [Source:HGNC Symbol;Acc:HGNC:3321], is expressed in 1 baseline experiment(s);

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ELK1

Project description:Homo sapiens ELK1, ETS transcription factor ELK1 [Source:HGNC Symbol;Acc:HGNC:3321], is differentially expressed in 108 experiment(s);

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