Single-Cell Landscape of Lymphoid and Myeloid Heterogeneity Across Type-Stratified Craniofacial Lesions in Polyostotic Fibrous Dysplasia

ABSTRACT: Polyostotic fibrous dysplasia (POFD) is a mosaic skeletal disorder driven by somatic GNAS mutations that constitutively activate Gsα-cAMP signaling, producing fibro-osseous craniofacial deformities. POFD lesions are histologically classified into three subtypes—Type I (connective-tissue predominant), Type II (cancellous-bone predominant), and Type III (sclerotic-bone predominant)—yet the immune microenvironment across these categories remains undefined. This study aims to dissect lymphoid and myeloid heterogeneity and inter-cellular communication networks among distinct POFD histological categories.

ORGANISM(S): Homo sapiens

PROVIDER: GSE346343 | GEO | 2026/10/21

REPOSITORIES: GEO