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IC - Experiment 3

ABSTRACT: Cells from 6 different IC patients were run in parallel with cells from their 6 different matched controls. Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE347 | GEO | 2003/07/14

SECONDARY ACCESSION(S): PRJNA84833

REPOSITORIES: GEO

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Project description:Normal bladder epithelial cell explants from 2 different normal controls were treated with APF from 2 different IC patients or mock APF from 2 different matched controls. Keywords: other

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Detection of Notch1-IC, Notch2-IC and EBNA2 target genes in human B cells

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Project description:Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic disease for which there is no effective treatment.Transforming Growth Factor-β (TGF-β) is thought to be involved in the pathogenesis of IC/PBS, and previous studies have shown that suggested that administration of TGF-β inhibitors significantly ameliorates IC/PBS in a mouse model.However, the molecular mechanism of the therapeutic effect of TGF-β inhibitors on IC/PBS has not been comprehensively analyzed. In this study, we show that TGF-β inhibitor administration ameliorated dysuria in IC/PBS mouse models using hydrogen peroxide through a variety of mechanisms.

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Transcription profiling of primary human astrocytes from brain treated by stathmin, poly IC and ultrapure LPS to examine the effects of different Toll-like receptor agonists

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