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HapMap Yoruban individuals vs CEPH reference

ABSTRACT: It is becoming clear that copy number polymorphism in the human genome is a significant form of genetic variation. We have developed a new method that uses SNP genotype data from parent-offspring trios and applied it to HapMap to conduct high-resolution detection of deletion polymorphism. Of the delections uncovered, approximately 100 have been experimentally validated using comparative genome hybridization on these tiling-resolution oligonucleotide microarrays. We identified a total of 586 distinct regions that harbor deletion polymorphisms in one or more of the parent-offspring trios. This new method will permit future identification of deletion polymorphisms from high density SNP data derived from parent-offspring trios or other family relationships. Keywords: comparative genomic hybridisation

ORGANISM(S): Homo sapiens

PROVIDER: GSE3474 | GEO | 2005/11/17

SECONDARY ACCESSION(S): PRJNA93281

REPOSITORIES: GEO

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