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DNA methylation data from human lymphoblasts [NimbleGen]

ABSTRACT: DNA methylation profiling of IAS subjects

ORGANISM(S): Homo sapiens

PROVIDER: GSE34778 | GEO | 2012/12/28

SECONDARY ACCESSION(S): PRJNA156209

REPOSITORIES: GEO

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DNA methylation data from human lymphoblasts [NimbleGen]

Project description:DNA methylation profiling of IAS subjects Lymphoblasts RNA isolated from Iowa Adoption Study participants to compare the relationship between DNA methylation and gene expression on a genome-wide scale

2012-12-28 | E-GEOD-34778 | biostudies-arrayexpress

DNA methylation data from human lymphoblasts [Illumina]

Project description:DNA methylation profiling of IAS subjects

2012-12-28 | GSE34777 | GEO

DNA methylation data from human lymphoblasts [Illumina]

2012-12-28 | E-GEOD-34777 | biostudies-arrayexpress

Expression data from human lymphoblasts [Affymetrix]

Project description:Transcriptional profiling of IAS subjects Lymphoblasts RNA isolated from Iowa Adoption Study participants to compare the relationship between DNA methylation and gene expression on a genome-wide scale

2012-12-28 | E-GEOD-34776 | biostudies-arrayexpress

Expression data from human lymphoblasts [Affymetrix]

Project description:Transcriptional profiling of IAS subjects

2012-12-28 | GSE34776 | GEO

Arsenic-Associated Differential DNA Methylation in Human Uroepithelial Cells

Project description:There is strong epidemiologic evidence supporting that exposure to inorganic arsenic (iAs) exposure is responsible for a myriad of adverse health effects, including carcinogenesis of the bladder. This research aimed to identify novel epigenetic biomarkers of iAs exposure in target cells within a human population. Here we assessed genome-wide, gene-specific promoter DNA methylation levels assessed in exfoliated human bladder uroepithelial cells (BECs) in relationship to BEC iAs, monomethylated As (MMAs), dimethylated As (DMAs), and total As (tAs) concentrations from 46 individuals with varying levels of As exposure in Chihuahua, Mexico. These analyses identified genes with increased methylation associated with BEC iAs(III+V), MMAs(III+V), and tAs(III+V). These genes were enriched for signaling related to metabolic disease and cancer.

2015-06-01 | GSE58499 | GEO

Genome-wide profiling of DNA methylation patterns in iAs-transformed cells

Project description:To examine the global impact of iAs on DNA methylation patterns. Genomic DNA was Bisulfite converted and analyzed using Mini methly-seq.

2017-03-08 | GSE85012 | GEO

Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition

Project description:To examine the global impact of iAs on DNA methylation patterns. Genomic DNA was bisulfite converted and analyzed using Infinium MethylationEPIC BeadChip.

2017-06-23 | GSE95232 | GEO

Blood DNA methylation profiles in a Dutch population

Project description:Genome wide DNA methylation profiling of whole blood in schizophrenia patients and healthy subjects of different ages. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 62 schizophrenia patients and 33 healthy subjects from Dutch descent.

2012-10-19 | GSE41169 | GEO

DNA methylation data from brain samples of human subjects with Huntington's disease

Project description:Human DNA methylation Beadchip v1.2 was used to profile n=475 samples from various brain regions of subjects with Huntington's disease and control samples. The main goal of the study was to relate Huntington's disease status to measures of epigenetic age acceleration based on DNA methylation data. To measure DNA methylation age, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID: 24138928.

2016-11-02 | GSE72778 | GEO

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