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Splenic T cells in dirty mice (cohoused with pet store mice) [I44]

ABSTRACT: This study is part of the immgenT Open Source Project, specifically IGT44, which focuses on characterizing splenic T cells in "dirty" mice (laboratory C57BL/6J mice cohoused with pet store mice).

ORGANISM(S): Mus musculus

PROVIDER: GSE347796 | GEO | 2026/09/22

REPOSITORIES: GEO

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Splenic T cells in dirty mice (cohoused with pet store mice) [I44]

Project description:Splenic T cells in dirty mice (cohoused with pet store mice) [I44]

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Splenic T cells in dirty mice in acute LCMV (armstrong) infection [I45]

Project description:This study is part of the immgenT Open Source Project, specifically from IGT45, which focuses on characterizing splenic T cells in "dirty" mice during acute lymphocytic choriomeningitis virus (LCMV, Armstrong strain) infection.

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Natural Microbial exposure populates the maternal fetal interface with diverse T cells.

Project description:scRNAseq was used to investigate how maternal microbial burden influences the immunology of the maternal fetal interface (MFI). Female mice werre cohoused with pet store mice for >4 weeks prior to conception and throughout gestation to naturalize maternal immunity. Cohoused dams were compared to specific pathogen free (SPF) control dams. Anti-CD45.2 IV labeling techniques were used to delineate immune cells in tissues from those in contact with circulation. IV labeling also permitted enrichment of placental (IV+) and decidal (IV-) tissue associated immune cells postprocessing. This is the first scRNAseq dataset to compare the immune cell populations from the MFI (combined placental and decidual tissue) of SPF and 'dirty' (pet store cohoused) dams. These data revealed significant changes to the immune cell composition and expansion of populations of T cells that phenocopy those described in the human decidua.

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Spleen and placenta T cells in pregnancy and post partum and SFB infection [I39]

Project description:This study is part of the immgenT Open Source Project, specifically from IGT39, which focuses on characterizing T cells from spleen- and placenta during pregnancy and postpartum states of SFB colonized mice. T cells were isolated from the uterus or decidua and spleen of female C57BL/6J mice (16 weeks old, wild-type), either virgin or at defined stages of pregnancy (E6.5, E12.5, E18.5) and at 30 days postpartum (30dpp). Mice were cohoused with segmented filamentous bacteria (SFB)-colonized Taconic mice for 2 weeks prior to timed matings. All samples derived from pooled mice.

2026-09-22 | GSE347794 | GEO

Dirty mice as an alternative for preclinical vaccine testing

Project description:Laboratory mice comprise an inexpensive and expeditious model organism for preclinical vaccine testing; however, vaccine immunogenicity often fails to adequately translate to humans. Recent reports indicate that reconstituting physiologic microbial experience to specific pathogen free (SPF) mice induces durable immunological changes that better recapitulate the human immune system. We examined the impact of microbial experience on responses to vaccination after cohousing laboratory mice with pet store mice. We demonstrate that human transcriptional responses to influenza vaccination are better recapitulated in cohoused mice. Induction of humoral responses by vaccination was dampened in cohoused mice and resulted in poor control upon challenge. Additionally, the establishment of protective heterosubtypic T cell immunity was compromised in cohoused mice. In summary, SPF mice exaggerated both humoral and T cell protection induced by influenza vaccines compared to cohoused mice, suggesting that reconstituting microbial experience in laboratory mice through cohousing may better inform preclinical vaccine testing.

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T cells in Foxp3-mutant mice [I24]

Project description:This study is part of the immgenT Open Source Project, specifically from IGT24, which focuses on profiling T cells in Foxp3-deficient and wild-type mice across multiple organs and timepoints.

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Spleen T cells in aging [I29]

Project description:This study is part of the immgenT Open Source Project, specifically IGT29, which focuses on characterizing T cells during aging in mice. It includes a spleen control at baseline (6-8-week-old C57BL/6J mouse).

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Liver kidney and lung T cells at baseline- scRNA-seq, CITE-seq and TCRab [I3]

Project description:This study is part of the immgenT Open Source Project, specifically from IGT3, which focuses on characterizing T cells from the liver, kidney, lung, and spleen at baseline in C57BL/6J mice. Both male and female wild-type mice at 6 weeks of age were included.

2026-09-15 | GSE307876 | GEO

Thymus - [I17, I18]

Project description:This study is part of the immgenT Open Source Project, specifically from IGT17 and IGT18, which focuses on the comprehensive profiling of immune cell populations in the thymus of mice. Includes spleen control at baseline (6-8 week-old C57BL/6J mouse).

2026-09-19 | GSE347307 | GEO

Gene expression profiling of PBMC from petstore mice, C57Bl/6 laboratory mice, and C57Bl/6 laboratory mice cohoused with petstore

Project description:Transcriptional analysis of immunological characteristics of petstore mice, C57Bl/6 laboratory mice, and C57Bl/6 laboratory mice cohoused with petstore. We hypothesized that cohousing would confer a basal transcriptional signature of immune activation to laboratory mice from petstore mice. Comparison of these data with existing human adult vs. neonatal PBMC expression profiling data (GSE27272) revealed close concordance of laboratory mice with human neonates, and of cohoused or petstore mice with human adults. Results highlight the impact of environment on the basal immune state and suggest that restoring physiological microbial exposure in laboratory mice could provide a relevant tool for modeling immunological events in free-living organisms, including humans. Total RNA was isolated from PBMC of C57Bl/6 laboratory mice, petstore mice and C57Bl/6 laboratory mice cohoused with petstore mice (at least after 60 days post-cohousing)and transcriptional comparison among 3 groups were performed.

2016-03-09 | E-GEOD-78979 | biostudies-arrayexpress

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