Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A habenula-enriched GPCR, GPR151, regulates behavioral sensitivity to inflammation

ABSTRACT: These are snRNA-seq data from one human habenula. We used these data to compare GPR151 and CHRM3 expression and Gpr151 and CHRNB4/CHAT expression from single nuclei in the human habenula to expression of these genes from a published mouse scRNA-seq dataset (Hashikawa, Y. et al. Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula. Neuron 106, 743-758 e745 (2020)). We also compared these data to those from Yalcinbas, E. A. et al. Transcriptomic Analysis of the Human Habenula in Schizophrenia. Am J Psychiatry 182, 991-1006 (2025).

ORGANISM(S): Homo sapiens

PROVIDER: GSE348268 | GEO | 2026/09/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The Habenular G-Protein-Coupled Receptor 151 regulates synaptic plasticity and nicotine intake

Project description:The habenula, an ancient small brain area in the epithalamus, densely expresses nicotinic acetylcholine receptors and is critical for nicotine intake and aversion. As such, identification of strategies to manipulate habenular activity may yield new approaches to treat nicotine addiction. Here we show that GPR151, an orphan G protein-coupled receptor (GPCR) highly enriched in the habenula of humans and rodents is expressed at presynaptic membranes and synaptic vesicles, and associates with synaptic components controlling vesicle release and ion transport. Deletion of Gpr151 inhibits evoked neurotransmission but enhances spontaneous miniature synaptic currents and eliminates short-term plasticity induced by nicotine. We find that GPR151 couples to the G-alpha inhibitory protein Gao1 to reduce cAMP levels in mice and in GPR151 expressing cell lines that are amenable to ligand screens. Gpr151-KO mice show diminished behavioral responses to nicotine, and self-administer greater quantities of the drug, phenotypes rescued by viral re-expression of Gpr151 in the habenula. These data identify GPR151 as a critical modulator of habenular function that controls nicotine addiction vulnerability.

2020-01-18 | GSE143854 | GEO

Relapse from nicotine abstinence increases the pacemaking frequency of cholinergic habenular neurons

2013-12-30 | GSE43164 | GEO

SeaIce, Espegrend, Microscosm, Mnemi

Project description:454 dataset for Hosia, et al. Torstensson et al. Dinasquet et al.

| PRJEB7907 | ENA

Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids

Project description:Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also causes cognitive impairment, neurotoxicity and neurodevelopmental deficits. Yet, the molecular mechanisms by which METH causes neurodevelopmental defects have remained elusive. Here we utilized human cerebral organoids and single-cell RNA sequencing (scRNA-seq) to study the effects of prenatal METH exposure on fetal brain development. Findings have been reported in Dang et al. 2021, Molecular Psychiatry.

2025-01-07 | GSE286054 | GEO

Relapse from nicotine abstinence increases the pacemaking frequency of cholinergic habenular neurons

Project description:The discovery of genetic variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster associated with heavy smoking and higher relapse risk has led to the identification of the midbrain habenula- interpeduncular axis as a critical relay circuit in the control of nicotine addiction Here we profile the cholinergic neurons of the medial habenula and identify the unique transcirptional features of this population of neurons. For each cell population, three independent TRAP replicates were collected, and total RNA from both the immunoprecipitate and unbound fractions were seperately amplified and hybridized. For each tissue, several representative unnbound fractions are provided to serve as controls. Biological replicates are GCRMA normalized within groups. Following averaging of replicates, we recommend further global normalization between groups, using affymetrix biotinylated controls, to correct for any broad biases in scanning and hybridization. Finally for many analyses, we also recommend filtering to remove those probesets with low IP/UB fold change values from each cell type(see PMID:20962086). Researchers can contact us for spreadsheets where these additional steps have been completed.

2013-12-30 | E-GEOD-43164 | biostudies-arrayexpress

Sequences tags expressed in ovules of Arabidopsis thaliana using Massively Parallel Signature Sequencing (MPSS)

Project description:We report the use of MPSS data to compare transcripts expressed in wild-type and sporocyteless mutant ovules All MPSS libraries were performed as described by Meyers et al (Nature Biotechnol. 2004 Aug;22(8):1006-11. Epub 2004 Jul 11.)

2013-08-21 | E-GEOD-50020 | biostudies-arrayexpress

Project description:Manavski et al

| PRJNA1192076 | ENA

Project description:Finn Et al.

| PRJNA433383 | ENA

Srikant et al. 2022

Project description:Srikant et al. 2022

| PRJEB53879 | ENA

Project description:Resende et al. 2021

| PRJNA721984 | ENA