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Integrative Multi-omics Analysis Reveals Molecular Signatures of Age-Related Decline in Vervet Skeletal Muscles

ABSTRACT: Age-related decline in skeletal muscle function, often manifesting as slower gait speed, contributes significantly to frailty and loss of independence. To uncover the molecular basis of this decline, we investigated coordinated changes across the transcriptome, miRNome, and methylome in vastus lateralis muscle from female vervet monkeys (Chlorocebus aethiops sabaeus) exhibiting normal versus declining gait speed.

ORGANISM(S): Homo sapiens Chlorocebus sabaeus

PROVIDER: GSE349369 | GEO | 2026/10/02

REPOSITORIES: GEO

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