Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of water restriction on gene expression in mouse renal medulla

ABSTRACT: In order to identify novel gene targets of vasopressin regulation in the renal medulla, we performed a cDNA microarray study on the inner medullary tissue of mice following a 48 hour water restriction protocol. Keywords: Stress Response

ORGANISM(S): Mus musculus

PROVIDER: GSE3498 | GEO | 2005/10/25

SECONDARY ACCESSION(S): PRJNA93327

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Effects of water restriction on gene expression in mouse renal medulla

Project description:In order to identify novel gene targets of vasopressin regulation in the renal medulla, we performed a cDNA microarray study on the inner medullary tissue of mice following a 48 hour water restriction protocol. Three renal medulla of 3 water restricted (WR) mice and three control mice (C) were hybridized against each other such that each WR sample was hybridized against each C sample.

2010-06-30 | E-GEOD-3498 | biostudies-arrayexpress

Vasopressin (AVP) and the V2R specific agonist dDAVP 7 day infusion into Aquaporin 1 knockout animals

Project description:Vasopressin, the antidiuretic hormone, acts on the renal collecting duct. In this experiment both vasopressin (AVP) and the V2R specific agonist dDAVP were infused into Aquaporin 1 knockout animals for 7 days. The aim of the experiment was to identify genes increased by vasopressin receptors in the renal medullary collecting ducts, in the absence of an increase in renal medullary osmolarity (the AQP1 knockouts are concentrating mechanism knockouts). All experiments used inner medulla tissue for the RNA isolation. Hybridizations were performed that compared kidney inner medulla total RNA from three control mice against kidney medulla total RNA from 3 mice infused with either arginine vasopressin (AVP) or des-amino-D-arginine vasopressin (dDAVP).

2007-10-06 | E-GEOD-5953 | biostudies-arrayexpress

Vasopressin (AVP) and the V2R specific agonist dDAVP 7 day infusion into Aquaporin 1 knockout animals

2007-10-07 | GSE5953 | GEO

Kidney inner medulla from mice treated with or without cisplatin

Project description:We are interested in the inner medulla of the kidney and how the nephrotoxic drug, cisplatin, may affect the transcriptome. Furthermore, we are interested in male and female inner medullary transcriptomic differences.

2023-01-01 | GSE195786 | GEO

Neutral amino acid transporter SNAT2 protects renal medulla from hypertonicity-induced ferroptosis

Project description:Hypertonicity in renal medulla is essential for urine concentration and water homeostasis. However, how renal medullary collecting duct cells (MCDs) survive and function under the harsh hypertonic stress remains incompletely understood. By using the RNA-seq technique, we identified SNAT2 (slc38a2) as a novel osmoresponsive neutral amino acid transporter in MCD cells. We found that hypertonic stress induced cell death of MCDs mainly via ferroptosis.

2023-02-15 | GSE206476 | GEO

Renal transcriptome of the desert adapted Jaculus jaculus during water restriction and rehydration

Project description:Jaculus jaculus were split into three experimental groups: control (water access ad libitum), dehydrated (11 days water restriction), and rehydrated (7 days water restriction followed by 3 days water ad libitum). Kidney samples were extracted and sequenced to investigate changes in gene expression during osmotic challenge in a desert adapted model.

2023-07-04 | GSE225470 | GEO

Microarray profiling of renal medulla / papilla and cortex during postnatal development

Project description:The aim of this study is to establish a comprehensive transcriptome atlas that enables identification of key molecular pathways and morphogenic events regulating postnatal renal medulla/papillary and cortex development. To achieve this, a microarray expression profiling was performed on postnatal day 0-90 renal medulla and cortex obtained from CD1 male mice.

2016-01-12 | GSE72128 | GEO

Renal medulla expression differences between hypertensive and normotensive patients

Project description:Identification of renal medulla genes whose expression differs between male individuals with high blood pressure and normal blood pressure using Affymetrix GeneChip Human Gene 1.0 ST Arrays.

2011-10-15 | GSE28360 | GEO

Protein quantification of mouse inner medulla (IM) sections using MS based proteomics - WT vs. Dicer(AQP2Cre+) mice

Project description:In this project we investigated the global proteome alteration of dissected mouse inner medulla (IM) sections between the WT and the Dicer(AQP2Cre+) mice. TMT labeling strategy was used to obtain protein quantification information from LC-MS based proteomic analysis.

2021-05-05 | PXD022327 | Pride

Renal medulla microRNA expression differences between hypertensive and normotensive patients

Project description:Identification of renal medulla microRNAs whose expression differs between male individuals with high blood pressure and normal blood pressure using Agilent Human miRNA Microarrays (V3, release 12.0).

2011-10-15 | GSE28344 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data