The genomic architecture of sickle cell disease in children from West Africa

ABSTRACT: Sickle cell disease (SCD) is caused by a pathogenic hemoglobin (Hb) mutation, yet patients can have dramatically variable clinical manifestations. Here we address the genetic basis of this clinical heterogeneity. Using a systems genetics approach, we performed whole blood gene expression analysis and eQTL analysis on different clinical phenotypes in SCD patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE35007 | GEO | 2014/07/01

SECONDARY ACCESSION(S): PRJNA151177

REPOSITORIES: GEO