The analysis of mRNA and miRNA clarified the immune regulation mechanism of rainbow trout ( Oncorhynchus mykiss ) head kidney under IHNV infection

ABSTRACT: The head kidney is a multifunctional organ that integrates hematopoiesis, antigen processing, immune signal transduction, antibody production and endocrine regulation to maintain the immune homeostasis of fish and resist pathogens. Several studies indicate that AS can produce functionally diverse protein isoforms and has become a vital regulatory mechanism in fish antiviral innate immunity. However, the mechanism of AS in antiviral response of head kidney is still unclear in rainbow trout. Accordingly, this study analyzed AS events in the head kidney of rainbow trout though RNA-seq. This study provided a theoretical basis for the study of AS response mechanism of rainbow trout antiviral, and also provided potential molecular targets for in-depth understanding of fish interferon signal transduction.

ORGANISM(S): Oncorhynchus mykiss

PROVIDER: GSE352277 | GEO | 2026/10/28

REPOSITORIES: GEO