Transcriptomics

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Cumulus cells genetic profile of patients stimulated with r-hLH or hCG evaluated with MicroArray analysis versus r-hFSH stimulated COCs


ABSTRACT: The aim of this study was to evaluate if different ovaric stimulation protocols modify gene expression profiles in COCs of infertile women. mRNA pools in COCs are essential for correct meiosis and activation of oocyte during fecondation and their alterations lead to reduced differentiation and oocyte functionality. In particular we tested the action of 2 different stimulation protocol on COCs transcriptome by MicroArray analysis of COCs after stimulation with r-hLH or h-CG versus COCs stimulated with r-hFSH. We identified genes and networks selectively altered after the different treatment protocols involved in proliferation and activity of COCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE35228 | GEO | 2012/06/28

SECONDARY ACCESSION(S): PRJNA152851

REPOSITORIES: GEO

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