Host lung transcriptome at 1 day after Francisella tularensis SCHU P9 challenge in mice immunized with ftt_0965c(tm) versus saline

ABSTRACT: Female C57BL/6J mice were immunized intranasally with 1e6 CFU of the Targetron insertion mutant ftt_0965c(tm) (Francisella tularensis subsp. tularensis SCHU P9 background) or with saline, rested for 21 days, and challenged intranasally with 100 LD50 SCHU P9 (5e3 CFU). Whole lungs were harvested at 1 day post-challenge (1 dpc; n = 8 mice per immunization group) and profiled on Agilent SurePrint G3 Mouse GE 8x60K one-color microarrays (design ID 028005; GPL10787). Log2 Processed Signal values exported from GeneSpring GX version 14.8, per-gene normalized to the mean across the 16 samples, were used for vaccine-versus-saline analyses in the accompanying manuscript. A separate bacterial discovery series is available as GEO GSE274776.

ORGANISM(S): Mus musculus

PROVIDER: GSE354314 | GEO | 2026/11/13

REPOSITORIES: GEO