Gene expression profiling data from sooty mangabeys treated with interferon alpha

ABSTRACT: In contrast to pathogenic HIV and SIV infection of humans and macaques, SIV infection of sooty mangabeys (SMs) is typically non-pathogenic despite high virus replication. A key feature of primary SIV infection of SMs is a strong type I interferon (IFN-I) response, characterized by massive up-regulation of interferon-stimulated genes (ISG), followed by rapid resolution during the acute-to-chronic phase transition and establishment of an immune quiescent state that persists throughout the chronic infection. Based on these observations we hypothesized that low levels of IFN-I signaling may be instrumental in preventing chronic immune activation and disease progression in SIV-infected SMs. We used microarrays to characterize gene expression changes induced by IFNalpha treatment.

ORGANISM(S): Cercocebus atys Macaca mulatta

PROVIDER: GSE35460 | GEO | 2012/07/10

SECONDARY ACCESSION(S): PRJNA152333

REPOSITORIES: GEO