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Analysis of liver RNA from SRSF3 hepatocyte knockout mice versus wild-type littermates

ABSTRACT: Livers from three SRSF3HKO mice and 3 wild-tyope littermates were used to analyze changes in exon utilization and gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE35686 | GEO | 2012/12/01

SECONDARY ACCESSION(S): PRJNA152413

REPOSITORIES: GEO

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Analysis of liver RNA from SRSF3 hepatocyte knockout mice versus wild-type littermates

Project description:Livers from three SRSF3HKO mice and 3 wild-tyope littermates were used to analyze changes in exon utilization and gene expression. two genotypes, three replicates each

2012-12-01 | E-GEOD-35686 | biostudies-arrayexpress

Analysis of RNA from liver tumors in SRSF3 hepatocyte knockout mice

Project description:RNA from three hepatocellular carcinomas from 24-month-old SRSF3HKO mice compared to RNA from non-tumorous liver from 24-month-old SRSF3HKO mice for changes in exon utilization and gene expression.

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Analysis of RNA from liver tumors in SRSF3 hepatocyte knockout mice

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Analysis of RNA from primary hepatocytes from hepatocyte-specific SRSF1 knockout mice vs. WT

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Analysis of RNA from primary hepatocytes from hepatocyte-specific SRSF1 knockout mice vs. WT

Project description:RNA from primary hepatocyte cultures from three 3-month-old SRSF1HKO mice compared to RNA from three 3-month-old WT mice for changes in exon utilization and gene expression. SRSF1 KO vs. WT, three replicates each.

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Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates.

Project description: Not available

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Gene expression of hepatocyte-specific Mcl-1 ko mice

2015-12-07 | GSE75730 | GEO

Gene expression of hepatocyte-specific Mcl-1 ko mice

Project description:Gene expression from livers of knock-out, hemizygous and wild-type mice at the age of , 8 and 12 months. Including tumor and non-tumor tissue of the same animals. AlbCre negative littermates were used as wild type controls. The hepatic gene expression of mice carrying a hepatocyte specific deletion of the anti-apoptotic protein Mcl-1 was analyzed at various age. Expression was compared between knock-out, hemizygous and wild-type littermates as well as between tumor and corresponding non-tumor tissue.

2015-12-07 | E-GEOD-75730 | biostudies-arrayexpress

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.

Project description: Not available

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Cyldko

Project description:Effect of Cyld inactivation in liver. The Cyld gene was conditionally inactivated specifically in the liver by crossing mice carrying floxed exon 9 allele of Cyld with Alfp-Cre transgenic mice. Liver RNAs from Cyld lox/lox-AlfpCre mice were compared with RNAs prepared from the livers of wild type littermates.

2012-02-01 | E-MEXP-3478 | biostudies-arrayexpress

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